B3555

BMP2, human

Name: BMP2, human
Brand: SIGMA

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

Bone Morphogenetic Protein 2 human, BMP-2

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All Photos(2)

About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

EC Number:

232-936-2

MDL number:

MFCD03097877

Product Name

Bone Morphogenetic Protein 2 human, ≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized powder

mol wt

26 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

solubility

water: soluble 0.100 mL, clear, colorless

UniProt accession no.

P12643

storage temp.

−20°C

Quality Level

200

Gene Information

human ... BMP2(650)

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Analysis Note

The biological activity is measured by its ability to induce alkaline phosphatase production by ATDC5 chondrogenic cells.

Physical form

Lyophilized from a 0.2 μm filtered buffered solution containing 0.5 mg bovine serum albumin.

Biochem/physiol Actions

Cellular responses to BMP-2 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. BMPs stimulate angiogenesis by inducing the production of VEGF-A by osteoblasts. Human, mouse, and rat BMP-2 demonstrate 100% homology.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000411134

0000093803

11170533

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Mineralization of three-dimensional osteoblast cultures is enhanced by the interaction of 1α,25-dihydroxyvitamin D3 and BMP2 via two specific vitamin D receptors.

Jiaxuan Chen et al.

Journal of tissue engineering and regenerative medicine, 10(1), 40-51 (2013-06-21)

1α,25-Dihydroxyvitamin D3 [1α,25(OH)2D3] and bone morphogenetic protein-2 (BMP2) are both used to stimulate osteoblastic differentiation. 1α,25(OH)2D3 regulates osteoblasts through classical steroid hormone receptor mechanisms and through rapid responses that are mediated by two receptors, the traditional vitamin D receptor (VDR)

Signal transduction by bone morphogenetic proteins.

M Kawabata et al.

Cytokine & growth factor reviews, 9(1), 49-61 (1998-08-28)

Bone morphogenetic proteins (BMPs) are multifunctional cytokines, which are members of the transforming growth factor-beta (TGF-beta) superfamily. Activities of BMPs are extracellularly regulated by BMP-binding proteins, Noggin and Chordin. BMPs bind to two different types of serine-threonine kinase receptors, type

The Histone Deacetylase Inhibitor (MS-275) Promotes Differentiation of Human Dental Pulp Stem Cells into Odontoblast-Like Cells Independent of the MAPK Signaling System.

Eun-Cheol Lee et al.

International journal of molecular sciences, 21(16) (2020-08-17)

The role of dental pulp stem cells (DPSCs) in dental tissue regeneration is gaining attention because DPSCs can differentiate into odontoblasts and other specialized cell types. Epigenetic modification has been found to play an important role in cell differentiation and

Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A.

Martine M L Deckers et al.

Endocrinology, 143(4), 1545-1553 (2002-03-19)

During bone formation and fracture healing there is a cross-talk between endothelial cells and osteoblasts. We previously showed that vascular endothelial growth factor A (VEGF-A) might be an important factor in this cross-talk, as osteoblast-like cells produce this angiogenic factor

Age-Independent Cartilage Generation for Synovium-Based Autologous Chondrocyte Implantation.

Ernst B Hunziker et al.

Tissue engineering. Part A, 21(13-14), 2089-2098 (2015-04-22)

The articular cartilage layer of synovial joints is commonly lesioned by trauma or by a degenerative joint disease. Attempts to repair the damage frequently involve the performance of autologous chondrocyte implantation (ACI). Healthy cartilage must be first removed from the

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