B7283

Benserazide hydrochloride

Name: Benserazide hydrochloride
Brand: SIGMA

≥98% (HPLC), solid, L-aromatic amino acid decarboxylase inhibitor

Synonym(s):

DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₅N₃O₅ · HCl

CAS Number:

14919-77-8

Molecular Weight:

293.70

NACRES:

NA.77

PubChem Substance ID:

24277886

UNSPSC Code:

12352125

EC Number:

238-991-9

MDL number:

MFCD00078571

Product Name

Benserazide hydrochloride, ≥98% (HPLC), solid

InChI

1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H

InChI key

ULFCBIUXQQYDEI-UHFFFAOYSA-N

SMILES string

Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O

biological source

synthetic

assay

≥98% (HPLC)

form

solid

solubility

H₂O: 10 mg/mL

originator

Roche

storage temp.

room temp

Quality Level

100
200

Gene Information

human ... DDC(1644)

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Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Benserazide has been used:

to inhibit dopa-decarboxylase
to induce dyskinesia
to test on purified bacterial TDCs to assess the extent to which it could affect bacterial decarboxylases
as a peripheral dopa decarboxylase inhibitor to treat mice

Biochem/physiol Actions

Benserazide can block HK2 enzymatic activity in vitro. It is used along with levodopa to treat Parkinson′s disease.

Inhibitor of L-aromatic amino acid decarboxylase.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Benserazide is a peripheral decarboxylase inhibitor.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Restoration of the dopamine transporter through cell therapy improves dyskinesia in a rat model of Parkinson?s Disease

Tomas D, et al.

PLoS ONE, 11(4), e0153424-e0153424 (2016)

Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine

Tillerson JL, et al.

Experimental Neurology, 178, 80-90 (2002)

Developmental and evolutionary basis for drought tolerance of the Anopheles gambiae embryo

Goltsev Y, et al.

Developmental Biology, 330(2), 462-470 (2009)

24 - Extrapyramidal movement disorders and spasticity

Waller DG, et al.

Medical Microbiology, 325-336 (2018)

Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2

Li W, et al.

Journal of Experimental & Clinical Cancer Research, 36(1), 58-58 (2017)

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