B7901

Boric acid

Name: Boric acid
Brand: SIGMA

suitable for electrophoresis, ≥99.5%

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About This Item

Linear Formula:

H₃BO₃

CAS Number:

10043-35-3

Molecular Weight:

61.83

PubChem Substance ID:

24892029

eCl@ss:

38120104

UNSPSC Code:

12161700

NACRES:

NA.25

EC Number:

233-139-2

MDL number:

MFCD00011337

Product Name

Boric acid, suitable for electrophoresis, ≥99.5%

InChI key

KGBXLFKZBHKPEV-UHFFFAOYSA-N

InChI

1S/BH3O3/c2-1(3)4/h2-4H

SMILES string

OB(O)O

grade

electrophoresis grade

vapor pressure

2.6 mmHg ( 20 °C)

assay

≥99.5%

form

powder

technique(s)

electrophoresis: suitable

impurities

≤0.005% Insoluble in methanol

pH

8.2-10.1

mp

160 °C (dec.) (lit.)

solubility

H₂O: 40 mg/mL, clear, colorless

density

1.43 g/cm³ at 20 °C

anion traces

chloride (Cl^-): ≤0.001%
phosphate (PO₄^3-): ≤0.001%
sulfate (SO₄^2-): ≤0.01%

cation traces

Ca: ≤0.005%
Fe: ≤0.001%
heavy metals (as Pb): ≤0.001%

suitability

suitable for electrophoresis (as a reagent)

storage temp.

room temp

Quality Level

200

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Related Categories

Biochemicals

Biological Buffers

Application

Boric acid has been used as a component of tris borate buffer:

for native polyacrylamide gel electrophoresis (PAGE) and denaturing urea-PAGE of tRNA samples(80)
for urea-polyacrylamide electrophoresis of RNA samples(81)
for agarose gel electrophoresis of DNA samples(82)

Biochem/physiol Actions

Boric acid is used in the periodontal therapy as an irrigation solution as it elicits bactericidal effects in microbial biofilms in root canal. Boric acid may favor osteoblastic activity and inhibit bone loss. It inhibits Candida albicans fungal infection and has potential to treat vaginal infection.

General description

Boric acid is a weak acid and is widely used in multi-purpose solutions (MPS) as a buffering agent. It is less toxic and non-volatile in nature.

pictograms

GHS08

signalword

Danger

hcodes

H360FD

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Antifungal mechanisms supporting boric acid therapy of Candida vaginitis

De Seta F, et al.

The Journal of Antimicrobial Chemotherapy, 63(2), 325-336 (2008)

Nonclinical safety evaluation of boric acid and a novel borate-buffered contact lens multi-purpose solution, Biotrue? multi-purpose solution

Lehmann DM, et al.

Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association, 33, S24-S32 (2010)

Antibacterial effect of different concentration of boric acid against enterococcus faecalis biofilms in root canal

Zan R, et al.

Marmara Dental Journal, 2, 76-80 (2013)

Mathematical modeling and experimental validation of the spatial distribution of boron in the root of Arabidopsis thaliana identify high boron accumulation in the tip and predict a distinct root tip uptake function.

Akie Shimotohno et al.

Plant & cell physiology, 56(4), 620-630 (2015-02-12)

Boron, an essential micronutrient, is transported in roots of Arabidopsis thaliana mainly by two different types of transporters, BORs and NIPs (nodulin26-like intrinsic proteins). Both are plasma membrane localized, but have distinct transport properties and patterns of cell type-specific accumulation

Novel and simple headspace in-tube microextraction coupled with capillary electrophoresis.

Hye Ryeo Lee et al.

Journal of chromatography. A, 1346, 117-122 (2014-05-09)

In liquid phase microextraction, high enrichment factors can be obtained using an acceptor phase of small volume. By hanging an acceptor drop at the separation capillary tip, single drop microextraction (SDME) can be in-line coupled with capillary electrophoresis (CE). The

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