C5024

Carbonic Anhydrase from bovine erythrocytes

Name: Carbonic Anhydrase from bovine erythrocytes
Brand: SIGMA

non-denaturing PAGE marker

Synonym(s):

Carbonate Dehydratase, Carbonate Hydrolyase

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All Photos(1)

About This Item

CAS Number:

9001-03-0

UNSPSC Code:

12352204

NACRES:

NA.54

EC Number:

232-576-6

MDL number:

MFCD00081467

EC Number:

4.2.1.1 (BRENDA, IUBMB)

Product Name

Carbonic Anhydrase from bovine erythrocytes, non-denaturing PAGE marker

form

lyophilized powder

mol wt

~29 kDa

suitability

suitable for marker for electrophoresis (non-denaturing PAGE)

storage temp.

−20°C

Quality Level

200

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Application

This product is used as a marker to determine the molecular mass of an unknown protein in non-denaturing electrophoresis systems. In such systems, proteins often retain their biological activity, thus allowing in-gel detection using specific substrate stains. This technique also facilitates the recovery of the active protein. The product yields 3 bands.

Preparation Note

0.9-1.4 mg/mL after reconstitution with 1 mL of water

pictograms

GHS08

signalword

Danger

hcodes

H334

pcodes

P261 - P284 - P501

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Lowering of elevated tissue PCO2 in a hemorrhagic shock rat model after reinfusion of a novel nanobiotechnological polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase that is an oxygen and a carbon dioxide carrier with enhanced antioxidant properties.

Yuzhu Bian et al.

Artificial cells, nanomedicine, and biotechnology, 41(1), 60-68 (2013-01-26)

Even though erythrocytes transport both oxygen and carbon dioxide, research on blood substitutes has concentrated on the transport of oxygen and its vasoactivity and oxidative effects. Recent study in a hemorrhagic shock animal model shows that the degree of tissue

Peroxisome proliferator activated receptor-α/hypoxia inducible factor-1α interplay sustains carbonic anhydrase IX and apoliprotein E expression in breast cancer stem cells.

Alessio Papi et al.

PloS one, 8(1), e54968-e54968 (2013-02-02)

Cancer stem cell biology is tightly connected to the regulation of the pro-inflammatory cytokine network. The concept of cancer stem cells "inflammatory addiction" leads to envisage the potential role of anti-inflammatory molecules as new anti-cancer targets. Here we report on

Lacking hypoxia-mediated downregulation of E-cadherin in cancers of the uterine cervix.

A Mayer et al.

British journal of cancer, 108(2), 402-408 (2013-01-17)

Experimental studies have established a causal connection between tumour hypoxia, hypoxia-associated proteome changes and downregulation of E-cadherin, the final common pathway of epithelial-to-mesenchymal transition (EMT). Our study aimed at elucidating the interrelationship of these processes in cancers of the uterine

Endocervical glandular neoplasia associated with lobular endocervical glandular hyperplasia is HPV-independent and correlates with carbonic anhydrase-IX expression: a Gynaecological Oncology Group Study.

S Y Liao et al.

British journal of cancer, 108(3), 613-620 (2013-01-10)

Lobular endocervical glandular hyperplasia (LEGH) is a rare lesion of the uterine cervix. It has been proposed that LEGH may represent a precursor lesion to a group of mucinous adenocarcinoma with gastric phenotype (GA) that is independent of high-risk human

Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas.

Nadia Lounnas et al.

Cancer letters, 333(1), 76-88 (2013-01-26)

The membrane-bound carbonic anhydrase isoforms CAIX and CAXII, underpin a pH-regulating system that enables hypoxic tumor cell survival. Here, we observed for the first time an upregulation of CAXII in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LL) cells. First we showed that

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