C5743

Cilastatin sodium salt

Name: Cilastatin sodium salt
Brand: SIGMA

powder, ≥98% (HPLC)

Synonym(s):

Cilastatin sodium

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₅N₂NaO₅S

CAS Number:

81129-83-1

Molecular Weight:

380.43

MDL number:

MFCD30488996

UNSPSC Code:

12352204

EC Number:

279-694-4

NACRES:

NA.77

Product Name

Cilastatin sodium salt, ≥98% (HPLC)

SMILES string

[Na+].S(C[C@H](N)C(=O)[O-])CCCC\C=C(/NC(=O)[C@@H]1C(C1)(C)C)\C(=O)O

InChI key

QXPBTTUOVWMPJN-QBNHLFMHSA-M

InChI

1S/C16H26N2O5S.Na/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);/q;+1/p-1/b12-6-;/t10-,11+;/m1./s1

biological source

synthetic (organic)

assay

≥98% (HPLC)

form

powder

solubility

water: 10 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

Quality Level

100

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Biochem/physiol Actions

Inhibitor of dehydropeptidase I

Inhibitor of the renal enzyme dehydropeptidase I and some bacterial zinc-containing β-lactamases. By these action, cilastatin suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy.

General description

Cilastatin sodium salt is off-white to yellowish-white, hygroscopic, amorphous compound. It is derivatized from heptenoic acid. Its molecular mass is 380.43 g.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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First-order derivative ultraviolet spectrophotometry of imipenem-cilastatin formulations.

Tabbouche OS and Soukkariyyeh I

Journal of Taibah University Medical Sciences, 9(3), 178-181 (2014)

In vivo real-time imaging reveals megalin as the aminoglycoside gentamicin transporter into cochlea whose inhibition is otoprotective.

Jinkyung Kim et al.

Proceedings of the National Academy of Sciences of the United States of America, 119(9) (2022-02-25)

Aminoglycosides (AGs) are commonly used antibiotics that cause deafness through the irreversible loss of cochlear sensory hair cells (HCs). How AGs enter the cochlea and then target HCs remains unresolved. Here, we performed time-lapse multicellular imaging of cochlea in live

Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver.

Saurav Roy Choudhury et al.

Cell, 178(5), 1205-1221 (2019-08-24)

A hallmark feature of inflammation is the orchestrated recruitment of neutrophils from the bloodstream into inflamed tissue. Although selectins and integrins mediate recruitment in many tissues, they have a minimal role in the lungs and liver. Exploiting an unbiased in vivo

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