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Merck

C7527

Choline chloride

BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98%

Synonym(s):

(2-Hydroxyethyl)trimethylammonium chloride

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About This Item

Linear Formula:
(CH3)3N(Cl)CH2CH2OH
CAS Number:
67-48-1
Molecular Weight:
139.62
UNSPSC Code:
12352205
NACRES:
NA.75
PubChem Substance ID:
24892968
EC Number:
200-655-4
Beilstein/REAXYS Number:
3563126
MDL number:
MFCD00011721

Product Name

Choline chloride, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98%

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

SMILES string

[Cl-].C[N+](C)(C)CCO

biological source

synthetic (organic)

product line

BioReagent

assay

≥98%

form

crystals

mol wt

Mw 139.62 g/mol

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

color

white

pH

5.0-6.5 (25 °C, 140 g/L)

mp

302-305 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

Quality Level

300

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Application

Choline chloride has been used:
  • as a component of choline acetyltransferase (ChAT) buffer and for choline uptake in cultured human neuroblastoma (SK-N-SH) cells
  • for choline standard curve generation for quantifying phospholipase D (PLD) activity
  • as a component of slice solution for the dissection of entorhinal-hippocampal brain slices

General description

Choline acetyltransferase substrate
Choline chloride is a quaternary ammonium salt and associates with hydrogen bond donors (HBD). It is essential for the vital physiological functions and is used as a nutritional additive. Choline is a source of methyl groups for methyl-transfer reactions.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF7998V
WXBF7765V
WXBF7625V
WXBF6706V
WXBF5929V

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Choline: an essential nutrient for public health
Zeisel SH and Da Costa KA
Nutr. Rev, 67(11), 615-623 (2009)
Harvie P Portugaliza et al.
Scientific reports, 9(1), 14595-14595 (2019-10-12)
Transmission of malaria parasites from humans to mosquito vectors requires that some asexual parasites differentiate into sexual forms termed gametocytes. The balance between proliferation in the same host and conversion into transmission forms can be altered by the conditions of
Synthesis and characterization of choline chloride based binary mixtures
Abbas Q and Binder L
ECS Transactions, 33(7), 49-59 (2010)
Apoptosis of bovine granulosa cells: Intracellular pathways and differentiation
Carou MC, et al.
Acta Histochemica, 119(5), 462-470 (2017)
Zhenglin Gu et al.
Cell reports, 31(10), 107740-107740 (2020-06-11)
Muscarinic acetylcholine receptors (mAChRs) are critically involved in hippocampal theta generation, but much less is known about the role of nicotinic AChRs (nAChRs). Here we provide evidence that α7 nAChRs expressed on interneurons, particularly those in oriens lacunosum moleculare (OLM)
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