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D6140

Demeclocycline hydrochloride

powder or crystals, suitable for cell culture

Synonym(s):

7-Chloro-6-demethyltetracycline hydrochloride, Demethylchlorotetracycline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C21H21ClN2O8 · HCl
CAS Number:
64-73-3
Molecular Weight:
501.31
NACRES:
NA.75
PubChem Substance ID:
24278380
UNSPSC Code:
12352207
EC Number:
200-592-2
MDL number:
MFCD00082371
Beilstein/REAXYS Number:
3849198
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Product Name

Demeclocycline hydrochloride, powder or crystals

assay

89.5-102.0% anhydrous basis

Quality Level

200

form

powder or crystals

technique(s)

cell culture | mammalian: suitable

solubility

soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

−20°C

SMILES string

Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O

InChI

1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1

InChI key

GVSJQNRGSCOSNJ-KBHRXELFSA-N

General description

Chemical structure: tetracycline

Biochem/physiol Actions

Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.
Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000436210
0000436210
0000298314
0000298314
0000137373

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Sierra H Root et al.
Stem cells (Dayton, Ohio), 38(6), 769-781 (2020-02-14)
Bone remodeling and regeneration are dependent on resident stem/progenitor cells with the ability to replenish mature osteoblasts and repair the skeleton. Using lineage tracing approaches, we identified a population of Dmp1+ cells that reside within cortical bone and are distinct
B Athanassiadis et al.
Australian dental journal, 55(2), 150-155 (2010-07-08)
The in vitro antimicrobial activity of a series of endodontic medicaments and their bases against biofilms of Enterococcus faecalis was investigated. The medicaments tested were Pulpdent paste, Ledermix paste, a 50:50 Ledermix and Pulpdent mixture, and a replica of Ledermix
Peter F Day et al.
Journal of endodontics, 37(8), 1052-1057 (2011-07-19)
There is evidence to suggest that Ledermix, placed as an intervisit root canal dressing, might improve periodontal healing after replantation of avulsed teeth. As a part of a multicenter randomized controlled trial, we aimed to compare the effect of 2
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