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Merck

E5406

Ethopropazine hydrochloride

≥98% (HPLC), butyrylcholinesterase inhibitor, powder

Synonym(s):

10-(2-Diethylaminopropyl)phenothiazine, 10-[2-(Diethylamino)propyl]phenothiazine hydrochloride, Dibutil hydrochloride, Parkin

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About This Item

Empirical Formula (Hill Notation):
C19H24N2S · HCl
CAS Number:
1094-08-2
Molecular Weight:
348.93
NACRES:
NA.77
PubChem Substance ID:
329799070
UNSPSC Code:
12352200
EC Number:
214-134-4
MDL number:
MFCD00012653

Product Name

Ethopropazine hydrochloride, ≥98% (HPLC), powder

InChI

1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H

InChI key

VXPCQISYVPFYRK-UHFFFAOYSA-N

SMILES string

Cl[H].CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: >5 mg/mL at ~60 °C, clear

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... CHRM1(1128)

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Related Categories

Biochem/physiol Actions

Ethoproprazine hydrochloride is an inhibitor of butyrylcholinesterase; antiparkinsonian
Ethoproprazine hydrochloride is an inhibitor of butyrylcholinesterase; antiparkinsonian. It reduces extrapyramidal motor effects, characteristic of Parkinson′s disease; also alleviates thermal hyperalgesia in rats.

Features and Benefits

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Ethopropazine hydrochloride possess anticholinergic, antihistamine and antiadrenergic properties.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000485583
0000485582
0000485583
0000485582
0000352042

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Transition Metal Complexes of Ethopropazine: Synthesis and Characterization
Debbeti V, et al.
American Journal of Chemistry, 2(6), 294-298 (2012)
Katherine C M Chew et al.
PloS one, 6(5), e19720-e19720 (2011-06-01)
Mutations in the parkin gene, which encodes a ubiquitin ligase (E3), are a major cause of autosomal recessive parkinsonism. Although parkin-mediated ubiquitination was initially linked to protein degradation, accumulating evidence suggests that the enzyme is capable of catalyzing multiple forms
Derek P Narendra et al.
PLoS biology, 8(1), e1000298-e1000298 (2010-02-04)
Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin recognizes damaged mitochondria, however, is unknown. Here, we
Nickie C Chan et al.
Human molecular genetics, 20(9), 1726-1737 (2011-02-08)
Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin-proteasome system (UPS) for widespread degradation of outer membrane
Min Fu et al.
Molecular biology of the cell, 24(8), 1153-1162 (2013-02-22)
Glycoprotein 78 (Gp78) is a critical E3 ubiquitin ligase in endoplasmic reticulum-associated degradation. Overexpression of Flag-tagged Gp78 (Flag-gp78), but not Flag-gp78 mutated in its RING-finger domain (Flag-RINGmut) with deficient ubiquitin ligase activity, induces mitochondrial fragmentation and ubiquitination and proteasome-dependent degradation
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Acetylcholine Synthesis and Metabolism

Acetylcholine is synthesized from acetyl coenzyme A and choline by the enzyme choline acetyltransferase. In addition to its synthesis in the liver, choline employed in acetylcholine production is derived from dietary sources.

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