F3388

Ferric citrate

Name: Ferric citrate
Brand: SIGMA

BioReagent, suitable for cell culture

Synonym(s):

Iron(III) citrate, Iron(III) citrate hydrate

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About This Item

Empirical Formula (Hill Notation):

C₆H₅FeO₇

CAS Number:

3522-50-7

Molecular Weight:

244.94

NACRES:

NA.75

PubChem Substance ID:

24894843

UNSPSC Code:

12352205

EC Number:

222-536-6

MDL number:

MFCD00013098

Product Name

Ferric citrate, BioReagent, suitable for cell culture

InChI key

NPFOYSMITVOQOS-UHFFFAOYSA-K

InChI

1S/C6H8O7.Fe/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3

SMILES string

OC12CC(=O)O[Fe](OC(=O)C1)OC2=O

biological source

synthetic (organic)

product line

BioReagent

technique(s)

cell culture | mammalian: suitable

solubility

hot water: 0.01 g/mL, clear, orange-yellow

shipped in

ambient

storage temp.

room temp

Quality Level

300

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Application

Ferric citrate provides a source of iron used in cell culture applications. It provides iron in a less toxic form than free iron salts. Ferric citrate has been used as medium supplement in human osteosarcoma cell (U2OS) culture, human embryonic kidney (HEK293) cells and adult primary cardiomyocytes.

Biochem/physiol Actions

Ferric citrate is used as a component of protein-free medium. It is used as a substitute for transferrin in mouse hybridomas culture. Ferric citrate enhances IgM production. It indirectly stimulates the mitogen-activated protein kinase (MAPK) by favoring high amphiregulin oncoprotein levels in colon cancer. Ferric citrate is effective in binding to phosphate in patients with dialysis-dependent chronic kidney disease.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Development of a protein-free medium with iron salts replacing transferrin for a human-human hybridoma

Nagira K, et al.

Bioscience, Biotechnology, and Biochemistry, 59(4), 743-745 (1995)

Nonantibiotic effects of fluoroquinolones in mammalian cells

Badal S, et al.

The Journal of Biological Chemistry, 290(36), 22287-22297 (2015)

Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells

Scheers NM, et al.

Oncotarget, 9(24), 17066-17066 (2018)

An essential cell-autonomous role for hepcidin in cardiac iron homeostasis

Lakhal-Littleton S, et al.

eLife, 5, e19804-e19804 (2016)

Safety and efficacy of ferric citrate in patients with nondialysis-dependent chronic kidney disease

Chertow GM, et al.

PLoS ONE, 12(11), e0188712-e0188712 (2017)

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