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Merck

F3520

Anti-von Willebrand Factor antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Von Willebrand Factor Antibody, Von Willebrand Factor Antibody - Anti-von Willebrand Factor antibody produced in rabbit, Anti-Factor VIII-Related Antigen

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00162556

Product Name

Anti-von Willebrand Factor antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

packaging

antibody small pack of 25 μL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using human tissue (Indirect Immunoperoxidase Labeling)
indirect immunofluorescence: 1:200 using formalin-fixed, paraffin-embedded sections of human tissue

UniProt accession no.

P04275

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

300

Gene Information

human ... VWF(7450)

Related Categories

Application

Anti-von Willebrand Factor antibody produced in rabbit has been used for:
  • western blot analysis and immunostaining
  • immunocytochemistry
  • immunohistochemistry
  • indirect immunofluorescence

Biochem/physiol Actions

It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII.
The antibody specifically reacts with the cytoplasm of human endothelial cells from normal and neoplastic blood and from lymphatic vessels. It also reacts with human endocardium, platelets and megakaryocytes. It may be used for immunohistological studies of the vascular structures in frozen tissue preparations and enzymatically pre-digested, formalin, methacarn, Bouin′s or ethanol-fixed and paraffin-embedded tissue sections.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Anti-von Willebrand Factor is produced in rabbit using purified von Willebrand factor (factor VIII R:Ag) as the immunogen.
Human von Willebrand factor (factor VIII R:Ag) is a 270 kDa multimeric plasma gylcoprotein. The von Willebrand factor has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. The factor is synthesized by endothelial cells and is also present in platelets and megakaryocytes.

Immunogen

von Willebrand Factor (Factor VIII-related antigen) from human plasma.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Preparation Note

Whole antiserum is purified to provide an IgG fraction of antiserum.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000513344
0000513344
0000488197
0000488197
0000488181

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G Moser et al.
Human reproduction (Oxford, England), 30(12), 2747-2757 (2015-10-24)
How is histiotrophic nutrition of the embryo secured during the first trimester of pregnancy? Rather than specifically focusing on invasion into spiral arteries, extravillous trophoblasts also invade into uterine glands (endoglandular trophoblast) from the very beginning and open them toward
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Journal of endodontics, 43(4), 588-595 (2017-03-05)
The aim of this study was to quantify vascular network formation capacity after angiogenic induction of human and swine dental pulp stem cells (DPSCs) in comparison with endothelial cells. Primary human DPSCs or swine DPSCs were induced in endothelial growth
Extravillous trophoblasts invade more than uterine arteries: evidence for the invasion of uterine veins
Moser G, et al.
Histochemistry and Cell Biology, 147(3), 353-366 (2017)
Activation of endothelial TrkB receptors induces relaxation of resistance arteries
Totoson P, et al.
Vascular Pharmacology, 106(3), 46-53 (2018)
Ying Chen et al.
Investigative ophthalmology & visual science, 55(10), 6968-6975 (2014-09-18)
The proinflammatory cytokine interleukin-17 (IL-17) has recently been shown to promote angiogenesis. In addition, a receptor for IL-17, IL-17 receptor C (IL-17RC), is enriched in patients with wet, age-related macular degeneration (AMD), a disease characterized by the formation of choroidal
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Related Content

Data Sheet - F3520

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