G019

Muscimol hydrobromide

Name: Muscimol hydrobromide
Brand: SIGMA

≥98% (HPLC), GABAA receptor agonist, solid

Synonym(s):

5-Aminomethyl-3-hydroxyisoxazole hydrobromide

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About This Item

Empirical Formula (Hill Notation):

C₄H₆N₂O₂ · HBr

CAS Number:

18174-72-6

Molecular Weight:

195.01

UNSPSC Code:

12352200

PubChem Substance ID:

24278168

NACRES:

NA.77

MDL number:

MFCD00055184

Product Name

Muscimol hydrobromide, ≥98% (HPLC), solid

SMILES string

Br[H].NCc1cc(O)no1

InChI

1S/C4H6N2O2.BrH/c5-2-3-1-4(7)6-8-3;/h1H,2,5H2,(H,6,7);1H

InChI key

OPZOJWHOZRKYQX-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

off-white to tan

solubility

H₂O: >10 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

Muscimol hydrobromide is a GABA_A receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Compensating Level-Dependent Frequency Representation in Auditory Cortex by Synaptic Integration of Corticocortical Input.

Max F K Happel et al.

PloS one, 12(1), e0169461-e0169461 (2017-01-04)

Robust perception of auditory objects over a large range of sound intensities is a fundamental feature of the auditory system. However, firing characteristics of single neurons across the entire auditory system, like the frequency tuning, can change significantly with stimulus

Vibrissa-based object localization in head-fixed mice.

Daniel H O'Connor et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(5), 1947-1967 (2010-02-05)

Linking activity in specific cell types with perception, cognition, and action, requires quantitative behavioral experiments in genetic model systems such as the mouse. In head-fixed primates, the combination of precise stimulus control, monitoring of motor output, and physiological recordings over

Cortical State Fluctuations during Sensory Decision Making.

Elina A K Jacobs et al.

Current biology : CB, 30(24), 4944-4955 (2020-10-24)

In many behavioral tasks, cortex enters a desynchronized state where low-frequency fluctuations in population activity are suppressed. The precise behavioral correlates of desynchronization and its global organization are unclear. One hypothesis holds that desynchronization enhances stimulus coding in the relevant

Behaviorally Selective Engagement of Short-Latency Effector Pathways by Motor Cortex.

Andrew Miri et al.

Neuron, 95(3), 683-696 (2017-07-25)

Blocking motor cortical output with lesions or pharmacological inactivation has identified movements that require motor cortex. Yet, when and how motor cortex influences muscle activity during movement execution remains unresolved. We addressed this ambiguity using measurement and perturbation of motor

Medial Septum Modulates Cellular Response Induced in Hippocampus on Microinjection of Cholinergic Agonists into Hypothalamic Lateral Supramammillary Nucleus.

Mohammed Z Ariffin et al.

Frontiers in neuroanatomy, 11, 79-79 (2017-10-03)

Cholinergic mechanisms in supramammillary nucleus (SuM), especially the lateral SuM (lSuM) modulates septo-hippocampal neural activity. The lSuM, as compared to the contiguous medial SuM (mSuM) has relatively dense projections to hippocampus and cingulate cortex (Cg). In the present study, we

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