G9910

Sodium glycodeoxycholate

Name: Sodium glycodeoxycholate
Brand: SIGMA

BioXtra, ≥97% (HPLC)

Synonym(s):

3α,12α-Dihydroxy-5β-cholan-24-oic acid N-(carboxymethyl)amide, Glycodeoxycholic acid sodium salt, Glycodesoxycholic acid, N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₄₂NNaO₅

CAS Number:

16409-34-0

Molecular Weight:

471.61

NACRES:

NA.25

PubChem Substance ID:

24895386

UNSPSC Code:

12161900

EC Number:

240-455-4

MDL number:

MFCD00036742

Product Name

Sodium glycodeoxycholate, BioXtra, ≥97% (HPLC)

InChI key

BMYWWGPEKRLDGW-ZXMGEDLUSA-N

InChI

1S/C26H43NO5.Na.H/c1-15(4-9-23(30)27-14-24(31)32)19-7-8-20-18-6-5-16-12-17(28)10-11-25(16,2)21(18)13-22(29)26(19,20)3;;/h15-22,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);;/t15-,16-,17-,18+,19-,20+,21+,22+,25+,26-;;/m1../s1

SMILES string

[Na].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCC(O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

description

anionic

product line

BioXtra

assay

≥97% (HPLC)

mol wt

471.61 g/mol

impurities

≤0.0025% Phosphorus (P)
≤0.1% Insoluble matter

CMC

2.1 mM

solubility

H₂O: 0.1 M, clear to slightly hazy, colorless to almost colorless

anion traces

chloride (Cl^-): ≤1%
sulfate (SO₄^2-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.011%
Cu: ≤0.0005%
Fe: ≤0.001%
K: ≤0.005%
NH₄⁺: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.003%

Quality Level

200

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Other Notes

Bile Salt

Application

Sodium glycodeoxycholate has been used in a study to develop more similar mimetic intestinal fluids to physiological fluids than those developed by mixed bile salt systems (MBS). It has also been used in a study to investigate Ca²⁺ buffering capability of bile salt micelles.

Biochem/physiol Actions

Induces apoptosis in hepatocytes; may induce DNA cleavage.

General description

Sodium glycodeoxycholate is a bile salt that can be used to form biomimicking environments.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Bile salt composition is secondary to bile salt concentration in determining hydrocortisone and progesterone solubility in intestinal mimetic fluids

Huda H Zughaid, et al.

International Journal of Pharmaceutics, 422, 7-7 (2012)

[Study on the mechanism of Ca2+-buffering by sodium glycodeoxycholate micelles].

Hu-He Chen et al.

Guang pu xue yu guang pu fen xi = Guang pu, 30(3), 748-752 (2010-05-26)

In the present article, NaGDC was used to study the Ca(2+)-buffering capability of bile salt micelles. NaGDC is a naturally occurring bile salt which constitutes approximately 10 molar percent of bile salt composition in gallbladder. The authors selected glycine conjugated

Identification and Quantification of Phytochemicals, Antioxidant Activity, and Bile Acid-Binding Capacity of Garnet Stem Dandelion (Taraxacum officinale).

Maricella K Gomez et al.

Journal of food science, 83(6), 1569-1578 (2018-05-29)

Dandelion (Taraxacum officinale) var. Garnet Stem was harvested from Texas and New Jersey for identification, quantification of phytochemicals, measurement of free radical scavenging activity, and bile acid binding capacity. The red midrib and petioles were extracted with methanol or ethanol

Understanding the Fate of Almond (Prunus dulcis (Mill.) D.A. Webb) Oleosomes during Simulated Digestion.

Domenico Trombetta et al.

Nutrients, 12(11) (2020-11-11)

Almond kernels contain phytochemicals with positive health effects in relation to heart disease, diabetes and obesity. Several studies have previously highlighted that almond cell wall encapsulation during digestion and particle size are factors associated with these benefits. In the present

Insight into the gastro-duodenal digestion resistance of soybean proteins and potential implications for residual immunogenicity.

Elisabetta De Angelis et al.

Food & function, 8(4), 1599-1610 (2017-03-16)

Soy is an important component of the human diet thanks to its nutritional value and high protein content; however, it also represents a risk for allergenic consumers due to its potential to trigger adverse reactions in sensitized individuals. The putative

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