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Merck

H7291

Interleukin-4 human

IL-4, potency:, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00151705

Product Name

Interleukin-4 human, IL-4, potency:, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

biological source

human

recombinant

expressed in HEK 293 cells

assay

>95% (SDS-PAGE)

form

lyophilized powder

potency

≤0.6 ng/mL EC50

quality

endotoxin tested

mol wt

dimer 14-19 kDa (glycosylated)

packaging

pkg of 1 mg
pkg of 10 μg
pkg of 100 μg

manufacturer/tradename

HumanZyme

technique(s)

cell culture | mammalian: suitable

impurities

<1 EU/μg

UniProt accession no.

P05112

storage temp.

−20°C

Quality Level

100

Gene Information

human ... IL4(3565)

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Analysis Note

The activity is determined by the dose-dependent simulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).

Biochem/physiol Actions

Interleukin-4 (IL-4) interacts with interleukin 13 and is an interleukin-4 receptor ligand. It regulates IgE and IgG1 production by B cells. IL-4 favors glial and neuronal differentiation and regulates differentiation of naive cluster of differentiation CD4+ T cells to the T helper type 2 (TH2) cells. Polymorphism in the IL-4 gene is implicated in immune and inflammatory disorders. In cerebral infarction, IL-4 levels are elevated.

General description

Interleukin-4 (IL-4) is a pleiotropic cytokine and a complex glycoprotein mapped to human chromosome 5q31.1. It is produced by mast cells, basophils and a subset of activated T cells.

Physical form

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Preparation Note

HumanKine Interleukin-4 (IL-4), expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 14-19 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Legal Information

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX8531
MKCX3639
MKCV8299
MKCV6911
MKCS9400

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IL-4: role in disease and regulation of production.
P Choi et al.
Clinical and experimental immunology, 113(3), 317-319 (1998-09-16)
Interleukin 4 Receptor
Muscle and Exercise Physiology, 13(4) (1998)
Neurogenesis, Inflammation, and Mental Health
Inflammation and Immunity in Depression, 13(4) (2018)
Robert Y L Zee et al.
Human molecular genetics, 13(4), 389-396 (2003-12-19)
Candidate gene polymorphisms related to inflammation, thrombosis and lipid metabolism have been implicated in the development of ischemic stroke. Using DNA samples collected at baseline in a prospective cohort of 14 916 initially healthy American men, we genotyped 92 polymorphisms
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