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Merck

H9523

Serotonin hydrochloride

≥98%, powder, neurotransmitter

Synonym(s):

3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, 5-Hydroxytryptamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H12N2O · HCl
CAS Number:
153-98-0
Molecular Weight:
212.68
NACRES:
NA.77
PubChem Substance ID:
24278124
UNSPSC Code:
12352200
MDL number:
MFCD00012686
Beilstein/REAXYS Number:
3570963

Product Name

Serotonin hydrochloride, powder

InChI

1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H

SMILES string

Cl[H].NCCc1c[nH]c2ccc(O)cc12

InChI key

MDIGAZPGKJFIAH-UHFFFAOYSA-N

description

Drug Control: Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

assay

≥98%

form

powder

drug control

Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

color

white to off-white

mp

149-154 °C (lit.)

solubility

H2O: 17 mg/mL
0.1 M HCl: 22 mg/mL
ethanol: 5.3 mg/mL

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... HTR3A(3359)

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Application

Serotonin hydrochloride hasbeen used: to study the mechanisms of 5-hydroxytryptamine receptor antagonistsregulate fibrosis in liver spheroids, to study its effects on theextracellular-related-kinase (ERK) phosphorylation in human embryonic kidneycells, in transwell assay, wound healing assay and tumor allograft assay incolon carcinoma cell line

Biochem/physiol Actions

Neurotransmitter.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Serotonin is a ubiquitous molecule found in all animals. It shows diverse effects in the central and peripheral nervous system (CAN/PNS). Serotonin acts as a hormone and as a mitogen. It is produced in the axon terminal present in the brain. Action potential induces the release of serotonin that diffuses across the synapse to turn on the post-synaptic receptors. Serotonin plays a crucialrole in development, respiration, thermoregulation, endocrine, cardiovascular, and gastrointestinal functions. It also plays a role in sensory perceptional behaviors such as the sleep-wake cycle, sex, mood, memory, aggression, pain sensitivity, learning, and cognition. Serotonin impacts several psychiatric disorders such as schizophrenia, anorexia nervosa, depression, and a range of anxiety disorders such as obsessive-compulsive disorder, panic attacks, and social phobia. Variations in serotonin levels are associated withimpulse-related disorders or personalities like substance abuse, gambling, attention deficit disorder, obsessive-control, and aggression.

Preparation Note

Solutions should be freshly prepared.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H361

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000497930
0000514172
0000521539
0000521539
0000514172

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Can I store solutions of Product H9523, Serotonin hydrochloride?

    Solutions of this product are unstable.  We recommend preparing this solution fresh for each application.

  6. Is Product H9523, Serotonin hydrochloride, the neurotransmitter serotonin?

    This product is the neurotransmitter serotonin.  Other synonyms for this product are 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, and 5-Hydroxytryptamine hydrochloride.

  7. What are the storage conditions for Product H9523, Serotonin hydrochloride?

    This product is a powder and should be refrigerated at 2-8°C. We do not recommend storing solutions of this product.

  8. Has Product H9523, Serotonin hydrochloride, been cell culture tested?

    No. We do not test this product for cell culture suitability.

  9. What is the purity of Product H9523, Serotonin hydrochloride?

    This product must be at least 98% pure according to our specifications.  The purity for individual lots can be found on the certificate of analysis.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Serotonin Receptors
Nichols David E and Nichols Charles D.
Chemical Reviews (2008)
Vinay Kumar Sharma et al.
Research square (2023-02-16)
5-Hydroxy tryptamine receptor 1E (5-HTR1E) is reported to activate cAMP and ERK pathways via its ligands and binding partners, but the detailed mechanism underlying the serotonin induced 5-HTR1E signaling is still not known. In the present study, we determined the
Sara Redenšek Trampuž et al.
Scientific reports, 14(1), 1396-1396 (2024-01-17)
Non-alcoholic steatohepatitis (NASH) is a major health problem leading to liver fibrosis and hepatocellular carcinoma, among other diseases, and for which there is still no approved drug treatment. Previous studies in animal models and in LX-2 cells have indicated a
Soaleha Shams et al.
Behavioral neuroscience, 131(6), 492-504 (2017-12-01)
Social isolation can be used to study behavioral, neural, and hormonal mechanisms that regulate interactions in social animals. Although isolation effects have been reported in social mammals and various fish species, systematic studies with isolated zebrafish are rare. Here, the
L F Mohammad-Zadeh et al.
Journal of veterinary pharmacology and therapeutics, 31(3), 187-199 (2008-05-13)
5-Hydroxytryptamine, or serotonin, is a biogenic amine most noted for its role as a neurotransmitter. Manipulation of serotonin in animal models was used as a tool for studying its role in humans. Through such research serotonin has been shown to
View All Related Papers

Articles

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

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