I0523

IL-2 mouse

Name: IL-2 mouse
Brand: SIGMA

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

Interleukin-2, T-cell growth factor, mIL-2, IL-2

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00164816

Product Name

Interleukin-2 from mouse, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

mouse

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

≤0.2 ng/mL ED₅₀

quality

endotoxin tested

mol wt

17.2 kDa

packaging

pkg of 5X20 μg
pkg of 20 μg

technique(s)

cell culture | mammalian: suitable

impurities

≤1.000 EU/μg

color

white

UniProt accession no.

P04351

storage temp.

−20°C

Quality Level

200

Gene Information

mouse ... Il2(16183)

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Analysis Note

Activity was determined by dose-dependent stimulation of murine CTLL-2 cells. ED₅₀ : ≤ 0.2 ng/ml (corresponds to a specific activity of 5 × 10⁶ units/mg)

Application

Interleukin-2 from mouse has been used to induce sepsis in rat model. It has also been used in dendritic epidermal T cell culture.

Biochem/physiol Actions

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long-term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of natural killer cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor. IL-2 expression is known to reduce with age and results in influenza infection, neoplasms and lethal autoimmunity. IL-2 participates in T cell proliferation and differentiation and controls the homeostasis of T cell. As a part of immune response, IL-2 stimulates the action of T helper cell 1 and 2 along with endothelial white blood cells of skeletal muscles. IL-2 regulation is controlled by c-rel protein. IL-2 is a neurotrophic molecule and has special functions in cortical, hippocampal, septal, cerebellar and retinal neurons.

General description

IL-2 (interleukin-2) codes for a pro-inflammatory cytokine. IL-2 is mostly expressed in T helper cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in 10 mM sodium citrate, pH 4.0.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000236613

0000155640

0000109780

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Decreased c-rel activation contributes to aberrant interleukin-2 expression in CD4+ T cells of aged rats

Gong Z, et al.

Molecular Immunology, 61, 1-6 (2014)

Protein kinases JAK and ERK mediate protective effect of interleukin-2 upon ganglion cells of the developing rat retina

Marra C, et al.

Journal of Neuroimmunology, 233(1-2), 120-126 (2011)

Interactions Between Epidermal Keratinocytes, Dendritic Epidermal T-Cells, and Hair Follicle Stem Cells.

Krithika Badarinath et al.

Methods in molecular biology (Clifton, N.J.), 1879, 285-297 (2018-06-14)

The interplay of immune cells and stem cells in maintaining skin homeostasis and repair is an exciting new frontier in cutaneous biology. With the growing appreciation of the importance of this new crosstalk comes the requirement of methods to interrogate

A rat model of early sepsis: relationships between gentamicin pharmacokinetics and systemic and renal effects of bacterial lipopolysaccharide combined with interleukin-2

Studena S, et al.

Biological & Pharmaceutical Bulletin, 35(10), 1703-1710 (2012)

Acute exhaustive exercise regulates IL-2, IL-4 and MyoD in skeletal muscle but not adipose tissue in rats

Neto JCR, et al.

Lipids in Health and Disease, 10, 97-97 (2011)

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