I2142

KN-62

Name: KN-62
Brand: SIGMA

≥95%, powder

Synonym(s):

(S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine

Select a Size

All Photos(1)

About This Item

Empirical Formula (Hill Notation):

C₃₈H₃₅N₅O₆S₂

CAS Number:

127191-97-3

Molecular Weight:

721.84

NACRES:

NA.77

PubChem Substance ID:

24895961

UNSPSC Code:

12352200

MDL number:

MFCD00083180

Product Name

KN-62, ≥95%, powder

InChI

1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1

SMILES string

O=S(OC1=CC=C(C[C@@H](C(N2CCN(C3=CC=CC=C3)CC2)=O)N(C)S(C4=CC=CC5=C4C=CN=C5)(=O)=O)C=C1)(C6=CC=CC7=C6C=CN=C7)=O

InChI key

RJVLFQBBRSMWHX-DHUJRADRSA-N

biological source

synthetic (organic)

assay

≥95%

form

powder

color

yellow

mp

130 °C

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL
methanol: 10 mg/mL
DMSO: 12 mg/mL
chloroform: 20 mg/mL

storage temp.

−20°C

Quality Level

200

Gene Information

human ... P2RX7(5027)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Bioactive Small Molecule Inhibitors

Biochem/physiol Actions

Selectively inhibits rat brain Ca²⁺/calmodulin-dependent protein kinase II.

Features and Benefits

This compound is featured on the Ca/CaMKs and P2 Receptors: P2X Ion Channel Family pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Antagonists of the P2X(7) receptor. From lead identification to drug development.

Simon D Guile et al.

Journal of medicinal chemistry, 52(10), 3123-3141 (2009-02-05)

The P2X7 receptor is an upstream regulator of dynamic blebbing and a pluripotency marker in human embryonic stem cells.

Nikki Jo-Hao Weng et al.

Stem cell research, 23, 39-49 (2017-07-04)

New methods are needed to reduce dynamic blebbing which inhibits cell attachment and survival during passaging of pluripotent stem cells. We tested the hypothesis that activation of the P2X7 receptor by extracellular ATP during passaging initiates dynamic blebbing. The P2X7

Regina Stark et al.

Science immunology, 3(30) (2018-12-16)

Tissue-resident memory T cells (TRM) are noncirculating immune cells that contribute to the first line of local defense against reinfections. Their location at hotspots of pathogen encounter frequently exposes TRM to tissue damage. This history of danger-signal exposure is an

Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma.

Ming Lu et al.

The Journal of endocrinology, 208(1), 31-39 (2010-10-27)

Intracellular calcium ([Ca(2+)](i)) is the most relevant modulator of parathyroid hormone (PTH) secretion. Uniquely, an increase in [Ca(2+)](i) results in an inhibition of PTH secretion, and it probably exerts its function via calcium-binding protein pathways. The ubiquitous calcium-binding proteins, calmodulin

Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation.

Diego Moncada et al.

Proceedings of the National Academy of Sciences of the United States of America, 108(31), 12931-12936 (2011-07-20)

Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term

View All Related Papers