I7908

IL-2 human

Name: IL-2 human
Brand: SIGMA

≥98% (SDS-PAGE and HPLC), recombinant, expressed in Pichia pastoris, lyophiilized powder, suitable for cell culture

Synonym(s):

IL-2, Interleukin-2, T-cell growth factor

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.75

MDL number:

MFCD00165721

Product Name

Interleukin-2 human, recombinant, expressed in Pichia pastoris, suitable for cell culture

biological source

human

recombinant

expressed in Pichia pastoris

assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

mol wt

predicted mol wt ~15 kDa

packaging

pkg of 10KU

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P60568

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

Gene Information

human ... IL2(3558)

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Analysis Note

The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2.

Application

Interleukin-2 human has been used to assess changes in tumor necrosis factor receptor 1 (TNFR1). It has also been used in TNFR2 expression on Tregs.

Biochem/physiol Actions

Interleukin 2 (IL2) is a pro-inflammatory cytokine. It consists of three subunits, in which the β subunit is important for receptor mediated signaling. IL2 enhances the development of T regulatory cells and plays a crucial role in antitumor immunity.

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-interferon and B cell growth factor secretion,and modulates the expression of the IL-2 receptor.

Physical form

Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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TNFR1 and TNFR2 expression and induction on human Treg cells from type 1 diabetic subjects

Heinrich M, et al.

Antibodies, 4(1), 34-47 (2015)

Comprehensive Epstein-Barr Virus Transcriptome by RNA-Sequencing in Angioimmunoblastic T Cell Lymphoma (AITL) and Other Lymphomas.

Nader Bayda et al.

Cancers, 13(4) (2021-02-10)

The Epstein-Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL) in more than 80% of cases. Few studies have focused on this association and it is not clear now what role the virus plays in this pathology. We

Monocytes complexed to platelets differentiate into functionally deficient dendritic cells.

Meera V Singh et al.

Journal of leukocyte biology, 109(4), 807-820 (2020-07-15)

In addition to their role in hemostasis, platelets store numerous immunoregulatory molecules such as CD40L, TGFβ, β2-microglobulin, and IL-1β and release them upon activation. Previous studies indicate that activated platelets form transient complexes with monocytes, especially in HIV infected individuals

Epstein-Barr Virus (EBV) Is Mostly Latent and Clonal in Angioimmunoblastic T Cell Lymphoma (AITL).

Racha Bahri et al.

Cancers, 14(12) (2022-06-25)

The Epstein-Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL), a peripheral T lymphoma of poor prognosis in at least 90% of cases. The role of EBV in this pathology is unknown. Using next-generation sequencing, we sequenced the

The main function of IL-2 is to promote the development of T regulatory cells

Malek, Th, et al.

Journal of Leukocyte Biology, 74(6) (2003)

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