I8280

Indomethacin

Name: Indomethacin
Brand: SIGMA

meets USP testing specifications

Synonym(s):

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid

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All Photos(4)

About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₆ClNO₄

CAS Number:

53-86-1

Molecular Weight:

357.79

UNSPSC Code:

12352101

NACRES:

NA.21

PubChem Substance ID:

24896136

EC Number:

200-186-5

Beilstein/REAXYS Number:

497341

MDL number:

MFCD00057095

Product Name

Indomethacin, meets USP testing specifications

InChI key

CGIGDMFJXJATDK-UHFFFAOYSA-N

InChI

1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

SMILES string

COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3

agency

USP/NF
meets USP testing specifications

assay

98.0-102.0%

form

powder

mode of action

enzyme | inhibits

Quality Level

200

Gene Information

human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743)
mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224), Ptgs2(19225)
rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)

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Related Categories

Antibiotics

Biochemicals

Cell Culture Supplements & Reagents

Chemistry & Biochemicals

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.

Used as a non-selective inhibitor of cyclooxygenases, COX1 and COX2, leading to reduced prostaglandin biosynthesis from arachidonic acid.

pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P301 + P310

Hazard Classifications

Acute Tox. 1 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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