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Merck

L7770

Lipopolysaccharides from Salmonella enterica serotype enteritidis

γ-irradiated, BioXtra, suitable for cell culture

Synonym(s):

LPS

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About This Item

UNSPSC Code:
12352201
NACRES:
NA.75
MDL number:
MFCD00131520

Product Name

Lipopolysaccharides from Salmonella enterica serotype enteritidis, γ-irradiated, BioXtra, suitable for cell culture

biological source

Salmonella enterica (Serotype enteritidis)

sterility

γ-irradiated

product line

BioXtra

form

lyophilized powder

purified by

gel-filtration chromatography

technique(s)

cell culture | mammalian: suitable

impurities

<1% Protein (Lowry)

color

white to yellow cast

solubility

water: 4.90-5.10 mg/mL, faintly hazy to hazy, colorless

storage temp.

2-8°C

Quality Level

200

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Application

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4).
Lipopolysaccharides from Salmonella enterica serotype enteritidis are used in cell culture and cell binding applications. It was used to study the role of inflammation in the progression of neuropathic pain and aneurysm.

Biochem/physiol Actions

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Other Notes

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000403178
0000349958
0000310456
0000301667
0000403178

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Elisabetta Liverani et al.
Journal of leukocyte biology, 95(2), 313-323 (2013-10-22)
Thienopyridines are a class of antiplatelet drugs that are metabolized in the liver to several metabolites, of which only one active metabolite can irreversibly antagonize the platelet P2Y12 receptor. Possible effects of these drugs and the role of activated platelets
Rosemary Fernandez et al.
Bio-protocol, 5(11) (2016-05-03)
The ability to assess the function of a range of cytokine, antigen receptor, and Toll-like receptor (TLR) signaling pathways in a range of immune cells could provide a kind of fingerprint of the state of the human immune system. The
Anita Mikołajczyk et al.
Toxins, 11(2) (2019-02-06)
Bacterial lipopolysaccharide (LPS) can contribute to the pathogenesis and the clinical symptoms of many diseases such as cancer, mental disorders, neurodegenerative as well as metabolic diseases. The asymptomatic carrier state of Salmonella spp. is a very important public health problem.
Ryan Gene Soderquist et al.
Pharmaceutical research, 27(5), 841-854 (2010-03-13)
Interleukin-10 (IL-10) is an anti-inflammatory molecule that has achieved interest as a therapeutic for neuropathic pain. In this work, the potential of plasmid DNA-encoding IL-10 (pDNA-IL-10) slowly released from biodegradable microparticles to provide long-term pain relief in an animal model
Anita Mikołajczyk et al.
Gut pathogens, 9, 73-73 (2017-12-20)
The present research was conducted to investigate the influence of a low, single dose of LPS, which does not result in any clinical symptoms of intoxication on the expression of selected neuropeptides within the intestines of the domestic pig. This
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Articles

Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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