L7895

Lipopolysaccharides from Salmonella typhosa

Name: Lipopolysaccharides from <I>Salmonella typhosa</I>
Brand: SIGMA

γ-irradiated, BioXtra, suitable for cell culture

Synonym(s):

LPS

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About This Item

UNSPSC Code:

12352201

NACRES:

NA.75

MDL number:

MFCD00131520

Product Name

Lipopolysaccharides from Salmonella typhosa, γ-irradiated, BioXtra, suitable for cell culture

biological source

bacterial (Salmonella typhosa)

sterility

γ-irradiated

product line

BioXtra

form

lyophilized powder

purified by

gel-filtration chromatography

technique(s)

cell culture | mammalian: suitable

impurities

<1% Protein (Lowry)

color

white to faint yellow

solubility

water: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow

storage temp.

2-8°C

Quality Level

200

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Related Categories

Biochemicals

Carbohydrates for Biochemical Research

Cell Culture Supplements & Reagents

Chemical Biology

Glycoconjugates

Application

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Lipopolysaccharides from Salmonella typhosa are used in cell culture and cell binding applications. The role of LPS in the secretion of TNF-α and IL-6 was studied in mouse spleen cell culture. It was used to study the role of inflammatory responses in multiple sclerosis.

Biochem/physiol Actions

Other Notes

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000370414

0000256112

0000198318

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Leucine-Histidine Dipeptide Attenuates Microglial Activation and Emotional Disturbances Induced by Brain Inflammation and Repeated Social Defeat Stress.

Yasuhisa Ano et al.

Nutrients, 11(9) (2019-09-12)

The number of patients with mental illnesses is rapidly increasing, and daily lifestyle is closely associated with the development of symptoms. It is suggested that inflammatory molecules derived from microglia play crucial roles for the pathophysiology of depression. In the

A biocompatible "split luciferin" reaction and its application for non-invasive bioluminescent imaging of protease activity in living animals.

Aurélien Godinat et al.

Current protocols in chemical biology, 6(3), 169-189 (2014-09-11)

The great complexity of many human pathologies, such as cancer, diabetes, and neurodegenerative diseases, requires new tools for studies of biological processes on the whole organism level. The discovery of novel biocompatible reactions has tremendously advanced our understanding of basic

Mycobacterium tuberculosis lipomannan induces apoptosis and interleukin-12 production in macrophages.

D N Dao et al.

Infection and immunity, 72(4), 2067-2074 (2004-03-25)

The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as a virulence factor of Mycobacterium tuberculosis, and modification of the terminal arabinan residues of this compound with mannose caps (producing mannosyl-capped LAM [ManLAM]) in M. tuberculosis or with phosphoinositol

Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity.

Joanne L Jones et al.

Brain : a journal of neurology, 133(Pt 8), 2232-2247 (2010-07-28)

Treatment of early relapsing-remitting multiple sclerosis with the lymphocyte-depleting humanized monoclonal antibody alemtuzumab (Campath [registered trade mark]) significantly reduced the risk of relapse and accumulation of disability compared with interferon β-1a in a phase 2 trial [Coles et al., (Alemtuzumab

Spontaneously hypertensive rats display reduced microglial activation in response to ischemic stroke and lipopolysaccharide.

Deborah De Geyter et al.

Journal of neuroinflammation, 9, 114-114 (2012-06-01)

For successful translation to clinical stroke studies, the Stroke Therapy Academic Industry Round Table criteria have been proposed. Two important criteria are testing of therapeutic interventions in conscious animals and the presence of a co-morbidity factor. We chose to work

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