Skip to Content
Merck

Key Documents

View All Documentation

M1275

Naproxen sodium

synthetic (organic), 98.0-102.0%, Prostaglandin H synthase 1 and 2 inhibitor, powder

Synonym(s):

(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C14H13NaO3
CAS Number:
26159-34-2
Molecular Weight:
252.24
NACRES:
NA.77
PubChem Substance ID:
57654352
UNSPSC Code:
12352200
EC Number:
247-486-2
MDL number:
MFCD00058507
Assay:
98.0-102.0%
Form:
powder
Quality level:
200
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Naproxen sodium, 98.0-102.0%

biological source

synthetic (organic)

Quality Level

200

assay

98.0-102.0%

form

powder

solubility

water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

originator

Bayer

SMILES string

[Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O

InChI

1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1

InChI key

CDBRNDSHEYLDJV-FVGYRXGTSA-M

Gene Information

human ... PTGS1(5742), PTGS2(5743)

General description

Naproxen belongs to phenylacetic acid class of Non-steroidal anti-inflammatory drugs (NSAIDs).

Application

Naproxen sodium has been used to evaluate the thermodynamics of biomolecular interaction with bovine and human serum albumin. It has also been used to evaluate its efficiency in reducing the response of spinal dorsal horn neurons to noxious knee joint rotation.

Biochem/physiol Actions

Naproxen binds preferably to serum albumin. The S-enantiomer of naproxen is 28-fold more potential as an anti-inflammatory drug compared to the R-isomer. The R-isomer is found to be a liver toxin and causes gastrointestinal disorders.
Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Still not finding the right product?

Explore all of our products under Naproxen sodium

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

hcodes

H302,H360

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCZ9146
MKCW6583
MKCV0146
MKCS5488
MKCR9926

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Discover Bioactive Small Molecules for Lipid Signaling Research

Discover Bioactive Small Molecules for Lipid Signaling Research

Binding thermodynamics of Diclofenac and Naproxen with human and bovine serum albumins: A calorimetric and spectroscopic study
Bou-Abdallah F, et al.
The Journal of Chemical Thermodynamics, 103, 299-309 (2016)
Jing Xia et al.
Plant communications, 4(6), 100632-100632 (2023-05-31)
The phytohormone auxin plays central roles in many growth and developmental processes in plants. Development of chemical tools targeting the auxin pathway is useful for both plant biology and agriculture. Here we reveal that naproxen, a synthetic compound with anti-inflammatory
Margarita Valero et al.
Langmuir : the ACS journal of surfaces and colloids, 26(13), 10561-10571 (2010-05-15)
The associative structures between F127 Pluronic micelles and four drugs, namely, lidocaine (LD), pentobarbital sodium salt (PB), sodium naproxen (NP), and sodium salicylate (SAL), were studied by small-angle neutron scattering (SANS). Different outcomes for the micellar aggregates are observed, which
View All Related Papers