M5815

Monoclonal Anti-Myogenin antibody produced in mouse

Name: Monoclonal Anti-Myogenin antibody produced in mouse
Brand: SIGMA

clone F12B, purified immunoglobulin, buffered aqueous solution

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01322371

Product Name

Monoclonal Anti-Myogenin antibody produced in mouse, clone F12B, purified immunoglobulin, buffered aqueous solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

F12B, monoclonal

form

buffered aqueous solution

mol wt

antigen 34 kDa

species reactivity

mouse, rat, human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1-2 μg/mL using rhabdomyosarcoma tissue sections
immunoprecipitation (IP): 2 μg using 1 mg protein lysate
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1 μg/mL

isotype

IgG1

UniProt accession no.

P15173

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Application

Monoclonal Anti-Myogenin antibody produced in mouse has been used in immunohistochemistry, immunofluorescence and western blotting.

Biochem/physiol Actions

Myogenin acts as a biomarker in rhabdomyosarcoma (RMS). It has a role in developmental processes, such as hematopoiesis, neurogenesis, myogenesis, tumor cell invasion and metastasis.

Myogenin acts as a regulator during myoblast and skeletal muscle differentiation. It is considered as a definite marker for skeletal muscle differentiation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Myogenin belongs to the basic helix-loop-helix (bHLH) superfamily.

Myogenin is a transcription factor present in the nucleus. It possesses an amino-acid rich region and a helix-loop-helix structure. The gene encoding it is localized on human chromosome 1q31-41 and has three exons.

Immunogen

rat recombinant myogenin (amino acids 30-224).

Physical form

Solution in phosphate buffered saline containing 0.08% sodium azide.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000497914

0000353496

SLCH6767

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Neuraminidase-1 mediates skeletal muscle regeneration

de Carvalho Neves J, et al.

Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1852(9), 1755-1764 (2015)

Evaluation of skeletal muscle regeneration in experimental model after malnutrition.

A Pertille et al.

Brazilian journal of biology = Revista brasleira de biologia, 77(1), 83-91 (2016-07-08)

The aim of this study was to analyze muscle regeneration after cryoinjury in the tibialis anterior muscle of young rats that were malnourished and then recovered. Forty Wistar rats were divided into a nourished group that received a normal protein

MRTF-A regulates myoblast commitment to differentiation by targeting PAX7 during muscle regeneration.

Ruhui Song et al.

Journal of cellular and molecular medicine, 25(18), 8645-8661 (2021-08-05)

Myocardin-related transcription factor-A/serum response factor (MRTF-A/SRF), a well-known transcriptional programme, has been proposed to play crucial roles in skeletal muscle development and function. However, whether MRTF-A participates in muscle regeneration and the molecular mechanisms are not completely understood. Here, we

Dysregulated Myogenesis in Rhabdomyosarcoma

Current Topics in Developmental Biology, 126(9), 285-297 (2018)

Myogenin expression in vulvovaginal spindle cell lesions: analysis of a series of cases with an emphasis on diagnostic pitfalls.

W Glenn McCluggage et al.

Histopathology, 63(4), 545-550 (2013-08-16)

Myogenin (myf4) is a nuclear transcription factor that is considered to be a sensitive and highly specific marker for skeletal muscle differentiation. Following the identification of focal strong nuclear staining with myogenin in two fibroepithelial polyps of the lower female

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