M8777

Morphine sulfate salt pentahydrate

Name: Morphine sulfate salt pentahydrate
Brand: SIGMA

μ opioid receptor agonist, powder

Synonym(s):

Morphine hemi[sulfate pentahydrate]

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All Photos(2)

About This Item

Empirical Formula (Hill Notation):

C₃₄H₄₀N₂O₁₀S · 5H₂O

CAS Number:

6211-15-0

Molecular Weight:

758.83

UNSPSC Code:

12352210

PubChem Substance ID:

329818069

NACRES:

NA.77

MDL number:

MFCD00150902

Product Name

Morphine sulfate salt pentahydrate,

SMILES string

O.O.O.O.O.OS(O)(=O)=O.CN1CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4O)c35.CN6CC[C@]78[C@H]9Oc%10c(O)ccc(C[C@@H]6[C@@H]7C=C[C@@H]9O)c8%10

InChI

1S/2C17H19NO3.H2O4S.5H2O/c2*1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;1-5(2,3)4;;;;;/h2*2-5,10-11,13,16,19-20H,6-8H2,1H3;(H2,1,2,3,4);5*1H2/t2*10-,11+,13-,16-,17-;;;;;;/m00....../s1

InChI key

GRVOTVYEFDAHCL-RTSZDRIGSA-N

form

powder

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
kontrollierte Droge in Deutschland

Quality Level

200

Gene Information

human ... OPRM1(4988)

solubility

ethanol: 1.8 mg/mL
H₂O: 64 mg/mL

originator

Baxter

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Related Categories

Bioactive Small Molecule Agonists

Bioactive Small Molecules

Biochem/physiol Actions

Narcotic analgesic; prototypic μ opioid receptor agonist; also agonist at κ opioid receptors.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

GHS07

signalword

Warning

hcodes

H302,H336

pcodes

P261 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

target_organs

Central nervous system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Coupling efficacy and selectivity of the human mu-opioid receptor expressed as receptor-Galpha fusion proteins in Escherichia coli.

L Stanasila et al.

Journal of neurochemistry, 75(3), 1190-1199 (2000-08-11)

Two constructs encoding the human micro-opioid receptor (hMOR) fused at its C terminus to either one of two Galpha subunits, Galpha(o1) (hMOR-Galpha(o1)) and Galpha(i2) (hMOR-Galpha(i2)), were expressed in Escherichia coli at levels suitable for pharmacological studies (0.4-0.5 pmol/mg). Receptors fused

Pharmacological study of dihydroetorphine in cloned mu-, delta- and kappa-opioid receptors.

S Katsumata et al.

European journal of pharmacology, 291(3), 367-373 (1995-11-30)

We investigated the binding characteristics of dihydroetorphine, 7,8-dihydro-7 alpha-[1-(R)-hydroxy-1-methylbutyl]-6, 14-endoethanotetrahydro-oripavine, and its effect on the inhibitory system of cyclic AMP production using cloned mu-, delta- and kappa-opioid receptors expressed on Chinese hamster ovary cells. The Ki values of dihydroetorphine for

Chronic morphine treatment alters NMDA receptor-mediated synaptic transmission in the nucleus accumbens.

G Martin et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(20), 9081-9089 (1999-10-12)

In a study of a possible substrate underlying morphine addiction, we examined NMDA receptor-mediated synaptic transmission of core nucleus accumbens neurons after chronic morphine treatment, using intracellular recording in a slice preparation of rat. We evoked pharmacologically isolated NMDA EPSCs

NADPH oxidase-mediated endothelial injury in HIV- and opioid-induced pulmonary arterial hypertension.

Stuti Agarwal et al.

American journal of physiology. Lung cellular and molecular physiology, 318(5), L1097-L1108 (2020-04-03)

We previously demonstrated that the combined exposure of human pulmonary microvascular endothelial cells (HPMECs) to morphine and viral protein(s) results in the oxidative stress-mediated induction of autophagy, leading to shift in the cells from early apoptotic to apoptosis-resistant proliferative status

Blockade of Toll-like receptor 4 attenuates morphine tolerance and facilitates the pain relieving properties of morphine.

Lori N Eidson et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(40), 15952-15963 (2013-10-04)

The ventrolateral periaqueductal gray (vlPAG) is an integral locus for morphine action. Although it is clear that glia contribute to the development of morphine tolerance, to date, the investigation of their role has been limited to spinal and medullary loci.

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