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Merck

O6503

L-Ornithine monohydrochloride

BioReagent, suitable for cell culture, ≥99%

Synonym(s):

(S)-2,5-Diaminopentanoic acid monohydrochloride

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About This Item

Empirical Formula (Hill Notation):
C5H12N2O2 · HCl
CAS Number:
3184-13-2
Molecular Weight:
168.62
UNSPSC Code:
12352209
NACRES:
NA.75
PubChem Substance ID:
24898036
EC Number:
221-678-6
Beilstein/REAXYS Number:
3625847
MDL number:
MFCD00064562

Product Name

L-Ornithine monohydrochloride, BioReagent, suitable for cell culture, ≥99%

InChI key

GGTYBZJRPHEQDG-WCCKRBBISA-N

InChI

1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1

SMILES string

Cl.NCCC[C@H](N)C(O)=O

biological source

microbial

product line

BioReagent

assay

≥99%

form

powder

packaging

pkg of 100 g
pkg of 25 g

technique(s)

cell culture | mammalian: suitable

impurities

ammonia and citrulline, essentially free

solubility

H2O: soluble 50 mg/mL, clear, colorless to very faintly yellow

Quality Level

300

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Application

L-Ornithine monohydrochloride has been used:
  • as a supplement in Dulbecco′s modified eagle medium (DMEM) for cell growth assays
  • as a component in the standard medium for primary human hepatocytes (PHH) culture
  • as a creatine synthesis inhibitor

Biochem/physiol Actions

L-ornithine acts as a precursor for polyamines. It may modulate the intake of food as an acute satiety signal in the neonatal chick brain.
L-Ornithine is used as a media supplement to support the biosynthesis of polyamines.

General description

L-Ornithine is the functional metabolite of L-arginine.
L-Ornithine is an amino acid that is not coded for by the genetic code. It is formed during the decomposition of argininine by arginase and participates in the urea cycle. Ornithine is the starting point for the formation of a family of polyamines that include spermine, spermidine and putrescine.

Other Notes

Product of arginine degradation by arginase

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000497230
0000497230
0000391535
0000334791
0000326699

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L-Ornithine is a potential acute satiety signal in the brain of neonatal chicks
Tran PV, et al.
Physiology & Behavior, 155, 141-148 (2016)
Arginine
Profiles of Drug Substances, Excipients, and Related Methodology, 27, 1-32 (2001)
Z N Canellakis et al.
The Yale journal of biology and medicine, 62(5), 481-491 (1989-09-01)
The polyamines and their derivatives are essential for life in eukaryotic and most prokaryotic cells, but their exact role in preserving cell function is not clear. These polyamines provide endogenous cations and thus participate in regulation of the intracellular pH;
Arginase 2 suppresses renal carcinoma progression via biosynthetic cofactor pyridoxal phosphate depletion and increased polyamine toxicity
Ochocki JD, et al.
Cell Metabolism, 27(6), 1263-1280 (2018)
Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
Ji L, et al.
Immunity, 51(2), 272-284 (2019)
View All Related Papers

Articles

L-Ornithine in Cell Culture

Discover L-ornithine, an important amino acid supplement, explore how L-ornithine is used in CHO and iPSC culture, and discover how poly-L-ornithine is used to enhance cell attachment.

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