P3075

Phenylarsine oxide

Name: Phenylarsine oxide
Brand: SIGMA

synthetic (organic), ≥97%, tyrosine phosphatase inhibitor, powder

Synonym(s):

Arzene, Oxophenylarsine, PAO

Select a Size

All Photos(3)

About This Item

Empirical Formula (Hill Notation):

C₆H₅AsO

CAS Number:

637-03-6

Molecular Weight:

168.02

NACRES:

NA.77

PubChem Substance ID:

24898387

UNSPSC Code:

12352119

EC Number:

211-275-3

MDL number:

MFCD00001990

Beilstein/REAXYS Number:

2935227

Product Name

Phenylarsine oxide, ≥97%, powder

InChI key

BQVCCPGCDUSGOE-UHFFFAOYSA-N

InChI

1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H

SMILES string

O=[As]c1ccccc1

biological source

synthetic (organic)

assay

≥97%

form

powder

color

white to off-white

mp

145-148 °C

solubility

DMSO: 50 mg/mL

Quality Level

100

Looking for similar products? Visit Product Comparison Guide

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Phenylarsine oxide has been used to infuse animals with a nigrostriatal transection, to determine whether peroxovanadium (pVa) would synergize with brain-derived neurotrophic factor (BDNF).

Biochem/physiol Actions

Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.

Phenylarsine oxide (PAO) can reduce the motility and sustainability of Setaria cervi. It has the ability to stimulate cyclosporin A-sensitive transition in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid). It acts as a stimulator of mitochondrial ion fluxes.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Phenylarsine oxide (PhAsO⁴) is a bifunctional SH group chemical. It is hydrophobic in nature.

pictograms

GHS06,GHS09

signalword

Danger

hcodes

H301 + H331,H410

pcodes

P261 - P264 - P271 - P273 - P301 + P310 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition.

M Wachtel et al.

Journal of cell science, 112 ( Pt 23), 4347-4356 (1999-11-24)

Regulation of epithelial and endothelial permeability is essential for proper function of compartmentalized organisms, and tyrosine phosphorylation plays an important role in this process. We analyzed the impact of protein tyrosine phosphatase (PTP) inhibition on the structure of endothelial junctional

Tyrosine phosphatase inhibition enhances neurotrophin potency and rescues nigrostriatal neurons in adult rats

Lu X, et al.

Experimental neurology, 178(2), 259-267 (2002)

Inhibition of setaria cervi protein tyrosine phosphatases by phenylarsine oxide: A proteomic and biochemical study

Singh N, et al.

Acta Tropica, 159, 20-28 (2016)

Phenylarsine oxide induces the cyclosporin A-sensitive membrane permeability transition in rat liver mitochondria

Lenartowicz E, et al.

Journal of Bioenergetics and Biomembranes, 23(4), 679-688 (1991)

PDK1 regulates auxin transport and Arabidopsis vascular development through AGC1 kinase PAX.

Yao Xiao et al.

Nature plants, 6(5), 544-555 (2020-05-13)

The 3-phosphoinositide-dependent protein kinase 1 (PDK1) is a conserved master regulator of AGC kinases in eukaryotic organisms. pdk1 loss of function causes a lethal phenotype in animals and yeasts, but only mild phenotypic defects in Arabidopsis thaliana (Arabidopsis). The Arabidopsis genome

View All Related Papers