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P4365

PJ-34 hydrochloride hydrate

Name: PJ-34 hydrochloride hydrate
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

PARP Inhibitor VIII, PJ 34 HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₇N₃O₂ · HCl · xH₂O

CAS Number:

344458-15-7

Molecular Weight:

331.80 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24898531

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to yellow

solubility

H₂O: 22 mg/mL

SMILES string

Cl[H].[H]O[H].CN(C)CC(=O)Nc1ccc2NC(=O)c3ccccc3-c2c1

InChI

1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2

InChI key

YCALIZUKAFUQCH-UHFFFAOYSA-N

Description

Application

PJ-34 hydrochloride hydrate has been used:

as a poly(ADP-ribose) polymerase (PARP) inhibitor 1 in rats to test the effect of PAPR1 in neuropathic pain
as a component of protein extraction buffer to enable visualization of the high-molecular-weight smear of PARylated proteins in various cell samples
as PARP inhibitor in murine MLE-12 epithelial cell line

Biochem/physiol Actions

PJ-34 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor.

PJ-34 is a prototypic poly(ADP-ribose) polymerase 1 (PARP-1) inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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PARP-1-regulated TNF-α expression in the dorsal root ganglia and spinal dorsal horn contributes to the pathogenesis of neuropathic pain in rats.

Yan Gao et al.

Brain, behavior, and immunity, 88, 482-496 (2020-04-14)

Emerging evidence has implicated poly-(ADP-ribose) polymerase 1 (PARP-1), a transcriptional coregulator, in a variety of inflammatory diseases. In the current study, the role of PARP-1 in neuropathic pain and the underlying mechanisms were investigated. Neuropathic pain was determined by assessing

Daidzein suppresses pro-inflammatory chemokine Cxcl2 transcription in TNF-α-stimulated murine lung epithelial cells via depressing PARP-1 activity.

Hai-yan Li et al.

Acta pharmacologica Sinica, 35(4), 496-503 (2014-03-19)

Daidzein (4',7-dihydroxyisoflavone) is an isoflavone exiting in many herbs that has shown anti-inflammation activity. The aim of this study was to investigate the mechanism underlying its anti-inflammatory action in murine lung epithelial cells. C57BL/6 mice were intranasally exposed to TNF-α

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation.

Garcia Soriano F et al.

Nature medicine, 7(1), 108-113 (2001-01-03)

Diabetic patients frequently suffer from retinopathy, nephropathy, neuropathy and accelerated atherosclerosis. The loss of endothelial function precedes these vascular alterations. Here we report that activation of poly(ADP-ribose) polymerase (PARP) is an important factor in the pathogenesis of endothelial dysfunction in

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