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P4543

Valproic acid sodium salt

Name: Valproic acid sodium salt
Brand: SIGMA

0.98, Ionophore, powder

Synonym(s):

2-propylpentanoic acid sodium, Sodium 2-propylpentanoate, Sodium valproate

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₅NaO₂

CAS Number:

1069-66-5

Molecular Weight:

166.19

UNSPSC Code:

12352106

eCl@ss:

42020819

PubChem Substance ID:

24277744

NACRES:

NA.77

EC Number:

213-961-8

MDL number:

MFCD00078604

Assay:

98%

Form:

powder

Quality level:

200

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Properties

Product Name

Valproic acid sodium salt, 98%

Quality Level

200

assay

98%

form

powder

solubility

H₂O: 50 mg/mL

originator

Abbott

SMILES string

[Na+].CCCC(CCC)C([O-])=O

InChI

1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1

InChI key

AEQFSUDEHCCHBT-UHFFFAOYSA-M

Gene Information

human ... ALDH5A1(7915)

Description

General description

The antiepileptic effects of Valproic acid (VPA) are achieved by reducing high-frequency neuronal firing through the blockage of voltage-gated sodium, potassium, and calcium channels. This medication affects the biochemical occurrence of aura and impacts pain perception by modulating GABA or glutamate-mediated neurotransmission. Additionally, VPA influences signaling systems such as the Wnt/beta-catenin and ERK pathways, interfering with inositol and arachidonate metabolism. Furthermore, VPA is crucial in expressing multiple genes involved in cell survival, transcription regulation, ion homeostasis, signaltransduction, and cytoskeletal modifications. Both immediate biochemical effects and long-term genomic influences explain the underlying effect of VPA in treating various conditions.

Valproic acid is an anticonvulsant and mood-stabilizing drug. It is used to treat epilepsy and bipolar disorder. Valproic acid helps to repress the Warburg effect and the development of tumor in neuroblastoma.

Application

Valproic acid sodium salt has been used:

in resazurin viability assay
to systematically study its effects of clinical doses on brain volume and offspring behavior
to study its effect on atherosclerotic lesion size
in genetic expression studies in mice

Biochem/physiol Actions

Anti-convulsant that also has efficacy as a mood stabilizer in bipolar disorder.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H361d

pcodes

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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