P7568

β-Acetyl-γ-O-alkyl-L-α-phosphatidylcholine from bovine heart lecithin

Name: β-Acetyl-γ-O-alkyl-<SC>L</SC>-α-phosphatidylcholine from bovine heart lecithin
Brand: SIGMA

≥99%, lyophilized powder

Synonym(s):

1-O-Alkyl-2-acetyl-sn-glycero-3-phosphocholine, 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine, AcGEPC, PAF, Platelet activating factor

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About This Item

CAS Number:

65154-06-5

UNSPSC Code:

12352211

NACRES:

NA.77

PubChem Substance ID:

24898858

MDL number:

MFCD00043214

Beilstein/REAXYS Number:

4220745

Product Name

β-Acetyl-γ-O-alkyl-L-α-phosphatidylcholine from bovine heart lecithin, ≥99%, lyophilized powder

InChI

1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(C)=O)COCCCCCCCCCCCCCCCC)=O

InChI key

HVAUUPRFYPCOCA-AREMUKBSSA-N

assay

≥99%

form

lyophilized powder

storage temp.

−20°C

Quality Level

200

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Biochem/physiol Actions

Phospholipid produced by lymphocytes, platelets and endothelial cells that induces platelet aggregation and is involved in inflammation, anaphylaxis and wound repair.

Packaging

Packaged under argon.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Platelet-activating factor phosphatidate, but not platelet-activating factor, is a powerful calcium ionophore in the human red cell.

F Bussolino et al.

Cell calcium, 5(5), 463-473 (1984-10-01)

Platelet-activating factor (1-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, PAF) is a potent inducer of shape-change, aggregation and secretion in platelets. PAF causes a rapid increase in intracellular calcium, but has no calcium gating effect in intact lipid bilayers. Human red cells (RBC) did not metabolize

PI3Kγ Regulatory Protein p84 Determines Mast Cell Sensitivity to Ras Inhibition-Moving Towards Cell Specific PI3K Targeting?

Julie R Jin et al.

Frontiers in immunology, 11, 585070-585070 (2020-11-17)

Mast cells are the major effector cells in immunoglobulin E (IgE)-mediated allergy. The high affinity IgE receptor FcεRI, as well as G protein-coupled receptors (GPCRs) on the mast cell surface signals to phosphoinositide 3-kinase γ (PI3Kγ) to initiate degranulation, cytokine

Signaling and functional competency of neutrophils derived from bone-marrow cells expressing the ER-HOXB8 oncoprotein.

Stephanie Saul et al.

Journal of leukocyte biology, 106(5), 1101-1115 (2019-06-20)

Neutrophils play a central role in immunity and inflammation via their intrinsic ability to migrate into inflamed tissue, to phagocytose pathogens, and to kill bacterial and fungi by releasing large quantities of superoxide anions and lytic enzymes. The molecular pathways