PLA0016

Rabbit anti-MDC1 Antibody, Affinity Purified

Name: Rabbit anti-MDC1 Antibody, Affinity Purified
Brand: SIGMA

Powered by Bethyl Laboratories, Inc.

Synonym(s):

Em:AB023051.5, KIAA0170, NFBD1, homologue to Drosophila photoreceptor protein calphotin, mediator of DNA-damage checkpoint 1, nuclear factor with BRCT domains 1

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Product Name

Rabbit anti-MDC1 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.

biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

technique(s)

immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2000-1:10000

accession no.

NP_055456.1

UniProt accession no.

Q14676

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

rabbit ... MDC1(9656)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

The epitope recognized by PLA0016 maps to a region between residues 475 and 525 of human Mediator of DNA Damage Checkpoint 1 using the numbering given in entry NP_055456.1 (GeneID 9656).

Other Notes

MDC1 is required for the S- and G2/M-checkpoint-mediated cell cycle arrest in response to DNA damage. MDC1 interacts with H2AX near sites of DNA double-strand breaks and recruits ATM kinase to foci of DNA damage. MDC1 also appears to regulate the function of other proteins involved in the DNA damage checkpoint such as BRCA1 and Chk2.

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Barrier-to-autointegration-factor (Banf1) modulates DNA double-strand break repair pathway choice via regulation of DNA-dependent kinase (DNA-PK) activity.

Joshua T Burgess et al.

Nucleic acids research, 49(6), 3294-3307 (2021-03-05)

DNA repair pathways are essential to maintain the integrity of the genome and prevent cell death and tumourigenesis. Here, we show that the Barrier-to-Autointegration Factor (Banf1) protein has a role in the repair of DNA double-strand breaks. Banf1 is characterized

COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks.

Amila Suraweera et al.

Communications biology, 4(1), 484-484 (2021-04-21)

Genomic stability is critical for normal cellular function and its deregulation is a universal hallmark of cancer. Here we outline a previously undescribed role of COMMD4 in maintaining genomic stability, by regulation of chromatin remodelling at sites of DNA double-strand

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