S143

(±)-6-Chloro-PB hydrobromide

Name: (±)-6-Chloro-PB hydrobromide
Brand: SIGMA

≥98% (HPLC), D1 dopamine receptor agonist, solid

Synonym(s):

(±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, (±)-SKF-81297 hydrobromide

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₆ClNO₂ · HBr

CAS Number:

71636-61-8

Molecular Weight:

370.67

UNSPSC Code:

12352200

PubChem Substance ID:

24277934

NACRES:

NA.77

MDL number:

MFCD00153782

Product Name

(±)-6-Chloro-PB hydrobromide, ≥98% (HPLC), solid

SMILES string

Br[H].Oc1cc2C(CNCCc2c(Cl)c1O)c3ccccc3

InChI

1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H

InChI key

RMIJGBMRNYUZRG-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to light tan

solubility

H₂O: 1.7 mg/mL
DMSO: >10 mg/mL
ethanol: 6.3 mg/mL

Quality Level

100

Gene Information

human ... DRD1(1812)

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Bioactive Small Molecule Agonists

Bioactive Small Molecules

Application

(±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal‑regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats.

Biochem/physiol Actions

(+/-)-6-Chloro-PB HBr is a full D₁ dopamine receptor agonist.

Disclaimer

Product is air and light sensitive

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Pharmacological manipulation of the dopaminergic system affects wheel-running activity in differentially active mice.

A M Knab et al.

Journal of biological regulators and homeostatic agents, 26(1), 119-129 (2012-04-06)

The genetic factors involved in the regulation of physical activity are not well understood. The dopamine system has been implicated in the control of voluntary locomotion and wheel running (WR) in mice and is thus a likely candidate as a

Differences between dorsal and ventral striatum in Drd1a dopamine receptor coupling of dopamine- and cAMP-regulated phosphoprotein-32 to activation of extracellular signal-regulated kinase.

Charles R Gerfen et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(28), 7113-7120 (2008-07-11)

Dopamine receptor signaling exhibits prominent plasticity that is important for the pathogenesis of both addictive and movement disorders. Psychoactive stimulants that activate the dopamine D(1) receptor (Drd1a) induce the rapid phosphorylation and activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in

Combinatorial topography and cell-type specific regulation of the ERK pathway by dopaminergic agonists in the mouse striatum.

Giuseppe Gangarossa et al.

Brain structure & function, 218(2), 405-419 (2012-03-29)

Therapeutic agents and drugs of abuse regulate the extracellular signal-regulated kinase (ERK) cascade signaling in the medium-sized spiny neurons (MSNs) of the striatum. However, whether this regulation is associated with specific cortical and thalamic inputs has never been studied. We

Inhibitory effects of dopamine on spinal synaptic transmission via dopamine D1-like receptors in neonatal rats.

K Kawamoto et al.

British journal of pharmacology, 166(2), 788-800 (2011-12-16)

Dopamine released from the endings of descending dopaminergic nerve fibres in the spinal cord may be involved in modulating functions such as locomotion and nociception. Here, we examined the effects of dopamine on spinal synaptic transmissions in rats. Spinal reflex

Relationship between D1 dopamine receptors, adenylate cyclase, and the electrophysiological responses of rat nucleus accumbens neurons.

P A Johansen et al.

Journal of neural transmission. General section, 86(2), 97-113 (1991-01-01)

The electrophysiological effects of three selective D1 dopamine (DA) receptor agonists, which exhibit different potencies and efficacies for stimulation of adenylate cyclase, were compared in the rat nucleus accumbens (NAc) using single unit recording and microiontophoretic techniques. The partial agonists

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