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Merck

S3007

Sodium salicylate

ReagentPlus®, ≥99.5% (titration)

Synonym(s):

2-Hydroxybenzoic acid sodium salt, Salicylic acid sodium salt, Sodium 2-hydroxybenzoate

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About This Item

Linear Formula:
HOC6H4COONa
CAS Number:
54-21-7
Molecular Weight:
160.10
UNSPSC Code:
12352302
NACRES:
NA.25
PubChem Substance ID:
24899540
EC Number:
200-198-0
Beilstein/REAXYS Number:
3732792
MDL number:
MFCD00002440
assay:
≥99.5% (titration)
form:
crystalline
solubility:
water: 575.7 g/L at 25 °C (77 °F)

Product Name

Sodium salicylate, ReagentPlus®, ≥99.5% (titration)

InChI key

ABBQHOQBGMUPJH-UHFFFAOYSA-M

InChI

1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1

SMILES string

[Na+].Oc1ccccc1C([O-])=O

product line

ReagentPlus®

assay

≥99.5% (titration)

form

crystalline

color

white

useful pH range

6.85 (26.3 °C)

mp

>300 °C (lit.)

solubility

water: 575.7 g/L at 25 °C (77 °F)

Quality Level

200

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Application

Sodium salicylate has been used:
  • to induce tinnitus, hyperacusis-like behavior in rats and infused directly into amygdala to measure local field potential.
  • to induce and confirm tinnitus by prepulse inhibition behavior (PPI) and its inhibition on learning and memory by Morris water maze test and subsequent gene expression studies in rats.
  • to enhance gamma amino butyric acid (GABA)ergic inhibition and enhance auditory response in the dorsal cortex of the inferior colliculus (ICd) measured by microiontophoretic technique.

General description

Sodium salicylate is the active ingredient in aspirin, commonly used as antipyretic, anti-inflammatory and analgesic drug. Sodium salicylate when taken in large quantities causes temporary hearing loss and tinnitus. Prolonged treatment with sodium salicylate reduces output from cochlea permanently, reduces compound action potential amplitude in vivo and neural degeneration in vitro. Sodium salicylate treatment in lateral amygdala alters tonography and excitability, causing hyperactivity in auditory cortex. Sodium salicylate impairs the expression of cellular-Finkel−Biskis−Jinkins murine osteogenic sarcoma virus (c-fos) and δ-FosB proteins in hippocampus region and affects spatial memory and learning. Sodium salicylate affects neurogenesis in dentate gyrus region of the brain.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

208.9 °F - Pensky-Martens closed cup

flash_point_c

98.3 °C - Pensky-Martens closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF7889V
WXBF6878V
WXBF6243V
WXBF5865V
WXBF5415V

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Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus
Niu H, et al.
BioMed Research International, 2018, 63-76 (2018)
Local application of sodium salicylate enhances auditory responses in the rat?s dorsal cortex of the inferior colliculus
Patel, Chirag R and Zhang, Huiming
Frontiers in Neurology, 5, 235-235 (2014)
Carmen S Padilla et al.
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