S5768

Monoclonal Anti-Synaptophysin antibody produced in mouse

Name: Monoclonal Anti-Synaptophysin antibody produced in mouse
Brand: SIGMA

clone SVP-38, ascites fluid

Synonym(s):

Synaptophysin Antibody, Synaptophysin Antibody - Monoclonal Anti-Synaptophysin antibody produced in mouse

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00164741

Product Name

Monoclonal Anti-Synaptophysin antibody produced in mouse, clone SVP-38, ascites fluid

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

SVP-38, monoclonal

mol wt

antigen 38 kDa

contains

15 mM sodium azide

species reactivity

pig, rat, human, guinea pig

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): 1:200 using rat cerebellum
indirect ELISA: suitable
western blot: suitable

isotype

IgG1

UniProt accession no.

P08247

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Application

Monoclonal Anti-Synaptophysin antibody has been used in western blotting.

Biochem/physiol Actions

Labels synaptophysin in neurons, neuromuscular junctions, benign and malignant neural tumors, paraganglia cells, hypophysis, pancreatic islet cells, and adrenal cells.

Synaptophysin participates in calcium dependent exocytosis. The antibody detects synaptophysin in many types of benign and malignant neural and epithelial neuroendocrine neoplasms. It is widely used as a potential marker to study the circulation of synapses in the brain and to discover the basic features of the life cycle of synaptic vesicles (SVs).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Synaptophysin (SYP) is an integral membrane glycoprotein of 38,000 Da and it has four membrane-spanning domains. Synaptophysin is localized to neurons, neuromuscular junctions, paraganglia cells, hypophysis, pancreatic islet cells, and adrenal cells. SYP gene is mapped to human chromosome Xp11.23. Monoclonal Anti-Synaptophysin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.

Immunogen

Rat retina synaptosome.

Physical form

Monoclonal Anti-Synaptophysin is provided as ascites fluid containing 0.1% sodium azide.

Preparation Note

For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000504569

0000504570

0000464997

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The distribution of synapsin I and synaptophysin in hippocampal neurons developing in culture.

Fletcher TL, et al.

The Journal of Neuroscience, 11(6), 1617-1626 (1991)

CD200 fusion protein decreases microglial activation in the hippocampus of aged rats.

Cox FF, et al.

Brain, behavior, and immunity, 26(5), 789-796 (2012)

Synaptophysin: a marker protein for neuroendocrine cells and neoplasms.

Wiedenmann B, et al.

Proceedings of the National Academy of Sciences of the USA, 83(10), 3500-3504 (1986)

Construction of two YAC contigs in human Xp11. 23?p11. 22, one encompassing the loci OATL1, GATA, TFE3, and SYP, the other linking DXS255 to DXS146.

Fisher SE, et al.

Genomics, 29(2), 496-502 (1995)

BDNF-induced synaptic delivery of AMPAR subunits is differentially dependent on NMDA receptors and requires ERK.

Li W and Keifer J

Neurobiology of Learning and Memory, 91(3), 243-249 (2009)

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