S7547

D-Sorbitol

Name: <SC>D</SC>-Sorbitol
Brand: SIGMA

≥98% (GC), BioXtra

Synonym(s):

D-Glucitol

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₄O₆

CAS Number:

50-70-4

Molecular Weight:

182.17

UNSPSC Code:

12352201

NACRES:

NA.25

PubChem Substance ID:

24899755

EC Number:

200-061-5

Beilstein/REAXYS Number:

1721899

MDL number:

MFCD00004708

Product Name

D-Sorbitol, ≥98% (GC), BioXtra

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CO

InChI key

FBPFZTCFMRRESA-JGWLITMVSA-N

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

vapor density

<1 (vs air)

vapor pressure

<0.1 mmHg ( 25 °C)

product line

BioXtra

assay

≥98% (GC)

form

powder or chunks

impurities

<0.001% Phosphorus (P)
<0.1% Insoluble matter

ign. residue

<0.1%

color

white

useful pH range

5.0-7.0 (25 °C, 182 g/L)

mp

98-100 °C (lit.)

solubility

H₂O: 1 M, clear, colorless (room temperature)

anion traces

chloride (Cl^-): <0.005%
sulfate (SO₄^2-): <0.01%

cation traces

Al: <0.0005%
Ca: <0.0005%
Cu: <0.0005%
Fe: <0.0005%
K: <0.005%
Mg: <0.0005%
NH₄⁺: <0.05%
Na: <0.005%
Pb: <0.001%
Zn: <0.0005%

Quality Level

200

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Related Categories

Biochemicals

Carbohydrates for Biochemical Research

Cell Culture Supplements & Reagents

Chemical Biology

High-Purity Biochemicals and Reagents

Application

May be used for washing spheroplasts and in isoelectric focusing to minimize endoosmotic flow in agarose gels. May be used to induce osmotic stress.

Biochem/physiol Actions

D-Sorbitol is a sugar alcohol that is commonly used as a sugar substitute. It occurs naturally and is also produced synthetically from glucose. The food industry uses D-sorbitol as an additive in the form of a sweetener, humectant, emulsifier, thickener, or dietary supplement. D-Sorbitol has also been found in cosmetics, paper, and pharmaceuticals. Naturally, D-sorbitol occurs widely in plants via photosynthesis, ranging from algae to higher order fruits of the family Rosaceae.

Other Notes

To gain a comprehensive understanding of our extensive range of Sugar alcohols for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Isoelectric focusing.

D E Garfin

Methods in enzymology, 182, 459-477 (1990-01-01)

Antibody-mediated growth inhibition of Plasmodium falciparum: relationship to age and protection from parasitemia in Kenyan children and adults.

Arlene E Dent et al.

PloS one, 3(10), e3557-e3557 (2008-10-30)

Antibodies that impair Plasmodium falciparum merozoite invasion and intraerythrocytic development are one of several mechanisms that mediate naturally acquired immunity to malaria. Attempts to correlate anti-malaria antibodies with risk of infection and morbidity have yielded inconsistent results. Growth inhibition assays

Assessment of the hepatic circulation in humans: new concepts based on evidence derived from a D-sorbitol clearance method.

G Molino et al.

The Journal of laboratory and clinical medicine, 131(5), 393-405 (1998-05-30)

D-Sorbitol (SOR) is safe, is easy to measure, and has an exceptionally high extraction ratio in the normal liver of 0.93+/-0.05 (mean+/-SD). Together with the general interest in hepatic hemodynamics, these facts motivated us to review the usefulness of this

FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress.

Reddy Ranjith K Sama et al.

Journal of cellular physiology, 228(11), 2222-2231 (2013-04-30)

FUsed in Sarcoma/Translocated in LipoSarcoma (FUS/TLS or FUS) has been linked to several biological processes involving DNA and RNA processing, and has been associated with multiple diseases, including myxoid liposarcoma and amyotrophic lateral sclerosis (ALS). ALS-associated mutations cause FUS to

An exploratory randomised double-blind and placebo-controlled phase 2 study of a combination of baclofen, naltrexone and sorbitol (PXT3003) in patients with Charcot-Marie-Tooth disease type 1A.

Shahram Attarian et al.

Orphanet journal of rare diseases, 9, 199-199 (2014-12-19)

Charcot-Marie-Tooth type 1A disease (CMT1A) is a rare orphan inherited neuropathy caused by an autosomal dominant duplication of a gene encoding for the structural myelin protein PMP22, which induces abnormal Schwann cell differentiation and dysmyelination, eventually leading to axonal suffering

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