S8753

Strychnine hydrochloride

Name: Strychnine hydrochloride
Brand: SIGMA

glycine receptor antagonist

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₂N₂O₂ · HCl

CAS Number:

1421-86-9

Molecular Weight:

370.87

NACRES:

NA.32

PubChem Substance ID:

24899812

UNSPSC Code:

12352210

EC Number:

215-826-9

MDL number:

MFCD00058174

Product Name

Strychnine hydrochloride,

InChI key

VLXYTKMPCOQKEM-ZEYGOCRCSA-N

InChI

1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1

SMILES string

Cl.[H][C@@]12CC(=O)N3c4ccccc4[C@]56CCN7CC(=CCO1)[C@]([H])(C[C@@]57[H])[C@]2([H])[C@]36[H]

Quality Level

100

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Bioactive Small Molecules

Application

Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.

Biochem/physiol Actions

Convulsant; glycine receptor antagonist not associated with the NMDA receptor.

Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.

pictograms

GHS06,GHS09

signalword

Danger

hcodes

H300 + H330,H410

pcodes

P260 - P264 - P271 - P273 - P284 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity

Bhati R, et al.

Journal of Ayurveda and integrative medicine, 3(2), 80-80 (2012)

Local inhibition shapes duration tuning in the inferior colliculus of guinea pigs.

Shankai Yin et al.

Hearing research, 237(1-2), 32-48 (2008-02-08)

Neural tuning to sound durations is a useful filter for the identification of a variety of sounds. Previous studies have shown that the interaction between excitatory and inhibitory inputs plays a role in duration selectivity in echolocating bats. However, this

Effect of Strychinine, a Glycine Inhibitor, on the Programmed Cell Death of Motoneurons during the Chick Development.

Kim JY

Experimental Neurobiology, 20(4), 176-180 (2011)

Horizontal cell feedback without cone type-selective inhibition mediates red?green color opponency in midget ganglion cells of the primate retina

Crook JD, et al.

The Journal of Neuroscience, 31(5), 1762-1772 (2011)

Biomarkers in Toxicology null

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