SAB2701819
Anti-PCNA antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
cb16, fb36g03, pcna, wu:fa28e03
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Product Name
Anti-PCNA antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
zebrafish, (Japanese Medaka)
technique(s)
immunohistochemistry: suitable
western blot: 500-3000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
zebrafish ... pcna(30678)
Application
Suggested starting dilutions are as follows: IHC-P: 1:100-1:1000, WB: 1:500-1:3000, IHC-Wm: 1:50-1:500, Immunostaining: Assay-dependent dilution. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Anti-PCNA antibody has been used in the detection of proliferating cells by immunofluorescence.
Anti-PCNA antibody has been used in the detection of proliferating cells by immunofluorescence.
Biochem/physiol Actions
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase′s processibility during elongation of the leading strand.
Proliferating cell nuclear antigen (PCNA) controls the production of the leading and lagging strands, which are required for the duplication of DNA. It acts as a cell cycle regulatory protein. This protein regulates apoptosis. PCNA is also involved in non-replicative DNA synthesis events.
Proliferating cell nuclear antigen (PCNA) controls the production of the leading and lagging strands, which are required for the duplication of DNA. It acts as a cell cycle regulatory protein. This protein regulates apoptosis. PCNA is also involved in non-replicative DNA synthesis events.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Proliferating cell nuclear antigen (PCNA) is a ring-shaped homotrimer protein, that is located at the center of the faithful duplication of eukaryotic genomes. Since it encircles the DNA, PCNA is also known as a sliding clamp. This gene is mapped to human chromosome 20p12.3.
Immunogen
Recombinant protein containing a sequence corresponding to a region within amino acids 31 and 222 of pcna according to NP_571479
Physical form
1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
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signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 3 - Skin Sens. 1
Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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PCNA (proliferating cell nuclear antigen)
Stoimenov I and Helleday T
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 16(3) (2012)
Luca Di Cesare et al.
Journal of morphology, 284(9), e21630-e21630 (2023-08-16)
In viviparous teleosts, intraovarian gestation occurs intrafollicularly, as in poeciliids, or intraluminally, as in goodeids and anablepids. Furthermore, there are two different forms of embryonic nutrition: lecithotrophy and matrotrophy; depending on the species, these can be exclusive or coexist during
Forging ahead through darkness: PCNA, still the principal conductor at the replication fork.
Katherine NC and George-Lucian M
Molecular Cell, 65(3), 380?392-380?392 (2017)
Fate bias during neural regeneration adjusts dynamically without recapitulating developmental fate progression.
Kei JNC, et al.
Neural Dev., 12(1), 12-12 (2017)
The prognostic value of PCNA expression in patients with osteosarcoma: A meta-analysis of 16 studies.
Wang X, et al.
Medicine, 96(41), e8254-e8254 (2017)
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