SAB4500797
Anti-AKT antibody produced in rabbit
affinity isolated antibody
Synonym(s):
AKT, AKT1 kinase, C-AKT, PKB, kinase Akt1
Product Name
Anti-AKT antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 55 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AKT1(207)
Application
Anti-AKT antibody produced in rabbit has been used in Western Blotting.
Biochem/physiol Actions
AKT serine/threonine kinase 1 (AKT1) acts as a regulator of cell-survival and anti-apoptotic functions. This protein has a crucial role in tumorigenesis. Mutations in the gene are associated with the pathogenesis of prostate cancer (PC). Elevated expression of the gene has been observed in human gastric cancer. Aberrations in AKT1 signaling leads to the development of schizophrenia.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Anti-AKT Antibody detects endogenous levels of total AKT protein.
AKT serine/threonine kinase 1 (AKT1), also called as v-akt murine thymoma viral oncogene homolog 1 or protein kinase B α (PKB-α), is encoded by the gene mapped to human chromosome 14q32. It is highly expressed in liver, muscle and adipocytes. The encoded protein is a member of the AKT family, which is characterized with an amino-terminal pleckstrin homology (PH) domain, a short α-helical linker and a carboxyl-terminal kinase domain.
AKT serine/threonine kinase 1 (AKT1), also called as v-akt murine thymoma viral oncogene homolog 1 or protein kinase B α (PKB-α), is encoded by the gene mapped to human chromosome 14q32. It is highly expressed in liver, muscle and adipocytes. The encoded protein is a member of the AKT family, which is characterized with an amino-terminal pleckstrin homology (PH) domain, a short α-helical linker and a carboxyl-terminal kinase domain.
Immunogen
The antiserum was produced against synthesized peptide derived from human Akt.
Immunogen Range: 90-139
Immunogen Range: 90-139
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Xin-Tong Fan et al.
Frontiers in endocrinology, 9, 633-633 (2018-11-09)
Studies of nesfatin-1 in glucose metabolism have become a topic of interest recently, however, the specific receptor for nesfatin-1 has not yet been identified. Some studies hinted at a connection between nesfatin-1 and the ghrelin receptor, growth hormone secretagogue receptor.
Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population.
Liu JM
Genetics and molecular research : GMR (2017)
Akt1/PKBa Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice*
Han Cho
The Journal of Biological Chemistry (2001)
PBX3 is associated with proliferation and poor prognosis in patients with cervical cancer
Hongfang Li
OncoTargets and Therapy (2017)
AKT plays a central role in tumorigenesis
Effat S
Nature Genetics (2004)
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