Product Name
Anti-USP30 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 58 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... USP30(84749)
Application
Anti-USP30, N-Terminal antibody has been used in western blotting.
Biochem/physiol Actions
USP30 controls atypical ubiquitin chains on mitochondria and PARK2 (parkinson juvenile disease protein 2) mediated mitophagy.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-USP30 Antibody detects endogenous levels of total USP30 protein.
USP30 (ubiquitin specific peptidase 30) is ubiquitin-specific deubiquitylase. It is located in the mitochondria. It is mapped to human chromosome 12q24.
Immunogen
The antiserum was produced against synthesized peptide derived from human USP30.
Immunogen Range: 31-80
Immunogen Range: 31-80
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Deubiquitinating enzymes regulate PARK2-mediated mitophagy
Wang Y, et al.
Autophagy, 11(4), 595-606 (2015)
USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
Cunningham CN, et al.
Nature Cell Biology, 17(2), 160-160 (2015)
Daily heat stress treatment rescues denervation-activated mitochondrial clearance and atrophy in skeletal muscle
Tamura Y, et al.
The Journal of Physiology, 593(12), 2707-2720 (2015)
A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease
Rovelet-Lecrux A, et al.
European Journal of Human Genetics, 20(6), 613-617 (2012)
Ding Yan et al.
Cell death discovery, 7(1), 211-211 (2021-08-13)
Deubiquitinates (DUBs) have been suggested as novel promising targets for cancer therapies. Accumulating experimental evidence suggests that some metal compounds have the potential to induce cancer cell death via inhibition of DUBs. We previously reported that auranofin, a gold(I)-containing agent
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