SML0264
AEG 3482
≥98% (HPLC)
Synonym(s):
6-Phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide
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About This Item
Empirical Formula (Hill Notation):
C10H8N4O2S2
CAS Number:
Molecular Weight:
280.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
faintly yellow to dark yellow
solubility
DMSO: ≥15 mg/mL
storage temp.
2-8°C
SMILES string
NS(=O)(=O)c1nn2cc(nc2s1)-c3ccccc3
InChI
1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16)
InChI key
MQUYTXDAVCOCMX-UHFFFAOYSA-N
Biochem/physiol Actions
AEG 3482 is an imidazothiadiazole sulfonamide of 281 D with an anti-apoptotic property.
AEG3284 is a compound that binds to heat shock protein 90 (HSP90), leading to heat shock factor 1 (HSF1) dependent expression of HSP70, an endogenous inhibitor of c-Jun N-terminal kinase (JNK) activity. Treatment of PC12 cells with AEF3284 blocks JNK dependent apoptosis.
AEG3284 is an indirect inhibitor of JNK activity; HSP90 binder.
Features and Benefits
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.
Amir H Salehi et al.
Chemistry & biology, 13(2), 213-223 (2006-02-24)
We describe a group of small-molecule inhibitors of Jun kinase (JNK)-dependent apoptosis. AEG3482, the parental compound, was identified in a screening effort designed to detect compounds that reduce apoptosis of neonatal sympathetic neurons after NGF withdrawal. We show that AEG3482
Karthiga Santhana Kumar et al.
SpringerPlus, 4, 19-19 (2015-01-28)
Medulloblastoma (MB) comprises four molecularly and genetically distinct subgroups of embryonal brain tumors that develop in the cerebellum. MB mostly affects infants and children and is difficult to treat because of frequent dissemination of tumor cells within the leptomeningeal space.
Zhen Ning Wee et al.
Nature communications, 6, 8746-8746 (2015-10-28)
Metastatic tumour recurrence due to failed treatments remains a major challenge of breast cancer clinical management. Here we report that interleukin-1 receptor-associated kinase 1 (IRAK1) is overexpressed in a subset of breast cancers, in particular triple-negative breast cancer (TNBC), where