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Merck

SML0421

SB265610

≥98% (HPLC)

Synonym(s):

1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea, N-(2-Bromophenyl)-N′-(7-cyano-1H-benzotriazol-4-yl)urea, SB 265610

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About This Item

Empirical Formula (Hill Notation):
C14H9BrN6O
CAS Number:
211096-49-0
Molecular Weight:
357.16
NACRES:
NA.77
PubChem Substance ID:
329825416
UNSPSC Code:
51111800
MDL number:
MFCD09971124

Product Name

SB265610, ≥98% (HPLC)

InChI

1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)

SMILES string

Brc1ccccc1NC(=O)Nc2ccc(C#N)c3nn[nH]c23

InChI key

SEDUMQWZEOMXSO-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 15 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Application

SB265610 has been used:
  • as a cysteine-amino acid-cysteine (CXC)-chemokine receptor type 2 (CXCR2) antagonist to study its effects on the binding of chemokine with G-protein coupled receptors (GPCR)
  • as a CX-chemokine receptor type 1 (CXCR1) inhibitor to study its effect on the chemotactic activity of chemokines on inflammatory cells
  • as a CXCR2 antagonist to study its effect on migration of neutrophils to the rat brain

Biochem/physiol Actions

SB265610 is a potent and selective CXCR2 chemokine receptor antagonist.
SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.

Features and Benefits

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000127299
0000114426
0000114425
0000110651
0000038717

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François Binet et al.
Science (New York, N.Y.), 369(6506) (2020-08-21)
In developed countries, the leading causes of blindness such as diabetic retinopathy are characterized by disorganized vasculature that can become fibrotic. Although many such pathological vessels often naturally regress and spare sight-threatening complications, the underlying mechanisms remain unknown. Here, we
Tao Zhang et al.
European journal of immunology, 48(6), 1059-1073 (2018-02-21)
Endometriosis affects women of reproductive age via unclear immunological mechanism(s). Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells with potent immunosuppressive and angiogenic properties. Here, we found MDSCs significantly increased in the peripheral blood of patients with
Zongmin Jiang et al.
Scientific reports, 7(1), 14510-14510 (2017-11-08)
Microenvironment (or niche)-providing chemokines regulate many important biological functions of tissue-specific stem cells. However, to what extent chemokines influence human pluripotent stem cells (hPSCs) is not yet completely understood. In this study, we applied protein array to screen chemokines found
Jing Zhao et al.
Scientific reports, 7(1), 16128-16128 (2017-11-25)
The pulsatile nature of blood flow exposes vascular smooth muscle cells (VSMCs) in the vessel wall to cyclic mechanical stretch (CMS), which evokes VSMC proliferation, cell death, phenotypic switching, and migration, leading to vascular remodeling. These responses have been observed
Meirong Du et al.
PloS one, 8(1), e54572-e54572 (2013-01-30)
Recent evidence indicates that CXCR2 signaling is crucial for cancer progression, and its antagonist SB225002 induces apoptosis in Wilms' tumor cells. Here, we investigated the effect of SB225002 on cell cycle progression and apoptosis induction in vitro, using CDDP-sensitive and
View All Related Papers

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