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Merck

SML0531

BIO-Acetoxime

≥98% (HPLC)

Synonym(s):

(2′Z,3′E)-6-Bromoindirubin-3′-acetoxime, (3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one, 6-Bromoindirubin acetoxime, 6-Bromoindirubin-3′-acetoxime, BIA

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About This Item

Empirical Formula (Hill Notation):
C18H12BrN3O3
CAS Number:
667463-85-6
Molecular Weight:
398.21
NACRES:
NA.77
PubChem Substance ID:
329825535
UNSPSC Code:
12352200
MDL number:
MFCD09037533
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

, dark red to purple

solubility

H2O: 2 mg/mL (clear solution, warmed)

storage temp.

2-8°C

SMILES string

CC(=O)O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4cc(Br)ccc34

InChI

1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)/b17-15-,22-16+

InChI key

MENDIXKFTXYTHJ-HPBPSMLHSA-N

Related Categories

Biochem/physiol Actions

BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. Also, BIO-Acetoxime induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor.

Features and Benefits

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000248335
0000220375
0000220375
0000248335
0000205063

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J Casper Swarte et al.
Journal of clinical medicine, 9(2) (2020-02-07)
Renal transplantation is life-changing in many aspects. This includes changes to the gut microbiome likely due to exposure to immunosuppressive drugs and antibiotics. As a consequence, renal transplant recipients (RTRs) might suffer from intestinal dysbiosis. We aimed to investigate the
Role of Sex Hormones in the Control of Vegetative and Metabolic Functions of Middle-Aged Women.
Vincenzo Monda et al.
Frontiers in physiology, 8, 773-773 (2017-10-20)
Qiushi Li et al.
Nature communications, 11(1), 1190-1190 (2020-03-07)
Genes in plant secondary metabolic pathways enable biosynthesis of a range of medically and industrially important compounds, and are often clustered on chromosomes. Here, we study genomic clustering in the benzylisoquinoline alkaloid (BIA) pathway in opium poppy (Papaver somniferum), exploring
Angela B Clark et al.
Clinical nutrition (Edinburgh, Scotland), 39(11), 3504-3511 (2020-04-11)
The Global Leadership Initiative on Malnutrition (GLIM) has developed new criteria for the diagnosis of malnutrition. This study aimed 1) to determine and compare malnutrition prevalence and risk using the GLIM criteria, European Society for Clinical Nutrition and Metabolism (ESPEN)
Xinyan Bi et al.
Nutrients, 10(3) (2018-03-08)
Few studies have been conducted to measure body composition in Asian populations. In this study, we determined the percent body fat (PBF) by using dual-energy X-ray absorptiometry (DEXA), air-displacement plethysmography (ADP or BOD POD), bioelectrical impedance analysis (BIA) and skinfold
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Glycogen Synthase Kinase 3 (GSK-3) Overview

Glycogen synthase kinase 3 (GSK-3) is a highly conserved family of serine/threonine kinases for over 100 proteins in many pathways. See a list of accepted GSK-3 modulators and related products.

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