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Merck

SML1538

NMDI14

≥97% (HPLC), nonsense-mediated RNA decay inhibitor, powder

Synonym(s):

4,5-Dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-3-thiophenecarboxylic acid ethyl ester, Ethyl 2-{[(6,7–dimethyl–3-oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate

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About This Item

Empirical Formula (Hill Notation):
C21H25N3O4S
CAS Number:
307519-88-6
Molecular Weight:
415.51
UNSPSC Code:
12352200
NACRES:
NA.77

Product Name

NMDI14, ≥97% (HPLC)

SMILES string

[s]1c(c(c(c1C)C)C(=O)OCC)NC(=O)CC2Nc3c(cc(c(c3)C)C)NC2=O

InChI key

QRLPSNLBUMVXBL-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 0.2 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Application

NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:
  • to study its effects on differentiating cardiomyocytes
  • to study its effects on zebrafish pdzk1 gene-knockout embryos
  • to analyze its effects on the apoptosis of colorectal cancer cells

Biochem/physiol Actions

NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.
Potent nonsense-mediated RNA decay (NMD) inhibitor

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000368406
0000368405
0000368406
0000368405
0000355891

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Michael Bordonaro et al.
Journal of Cancer, 10(2), 287-292 (2019-02-06)
Deregulated Wnt signaling initiates most cases of colorectal cancer (CRC). Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Nonsense mediated decay (NMD)
Greg H P Ngo et al.
Nature communications, 12(1), 3849-3849 (2021-06-24)
DNA-RNA hybrid structures have been detected at the vicinity of DNA double-strand breaks (DSBs) occurring within transcriptional active regions of the genome. The induction of DNA-RNA hybrids strongly affects the repair of these DSBs, but the nature of these structures
Xinyun Chen et al.
Nature communications, 12(1), 89-89 (2021-01-06)
The RNA-binding protein QKI belongs to the hnRNP K-homology domain protein family, a well-known regulator of pre-mRNA alternative splicing and is associated with several neurodevelopmental disorders. Qki is found highly expressed in developing and adult hearts. By employing the human
Jiaheng Xie et al.
Investigative ophthalmology & visual science, 62(3), 29-29 (2021-03-23)
The human PDZK1 gene is located in a genomic susceptibility region for neurodevelopmental disorders. A genome-wide association study identified links between PDZK1 polymorphisms and altered visual contrast sensitivity, an endophenotype for schizophrenia and autism spectrum disorder. The PDZK1 protein is

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