SML3335
DIPQUO
≥98% (HPLC)
Synonym(s):
6,8-Dimethyl-3-(4-phenyl-1H-imidazol-5-yl)-2(1H)-quinolinone, 6,8-Dimethyl-3-(4-phenyl-1H-imidazol-5-yl)quinolin-2(1H)-one, RU 0226606
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About This Item
Empirical Formula (Hill Notation):
C20H17N3O
CAS Number:
Molecular Weight:
315.37
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Product Name
DIPQUO, ≥98% (HPLC)
SMILES string
O=C1NC2=C(C)C=C(C)C=C2C=C1C3=C(C4=CC=CC=C4)N=CN3
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Activator of the bone marker alkaline phosphatase (ALP) that promotes osteogenesis; promotes activation of the β isoform of p38 MAP kinase
DIPQUO is a potent activator of the bone marker alkaline phosphatase (ALP) that promotes osteogenesis in human MSCs and zebrafish. DIPQUO potently induces osteoblast differentiation. It promotes bone formation and regeneration in zebra fish. It appears that DIPQUO promotes activation of the β isoform of p38 MAP kinase
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-?
Cell Chemical Biology, 26 (2019)
Brandoch Cook et al.
The Journal of biological chemistry, 296, 100696-100696 (2021-04-26)
Bone fractures are common impact injuries typically resolved through natural processes of osteogenic regeneration and bone remodeling, restoring the biological and mechanical function. However, dysfunctionality in bone healing and repair often arises in the context of aging-related chronic disorders, such
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