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Merck

SML3410

EMD638683

≥98% (HPLC)

Synonym(s):

EMD 638683, EMD-638683, N′-[2-(3,5-Difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide

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About This Item

Empirical Formula (Hill Notation):
C18H18F2N2O4
CAS Number:
1181770-72-8
Molecular Weight:
364.34
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
MFCD25541743

Key Documents

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Product Name

EMD638683, ≥98% (HPLC)

InChI

1S/C18H18F2N2O4/c1-3-13-9(2)15(23)5-4-14(13)17(25)21-22-18(26)16(24)10-6-11(19)8-12(20)7-10/h4-8,16,23-24H,3H2,1-2H3,(H,21,25)(H,22,26)

InChI key

SSNAPUUWBPZGOY-UHFFFAOYSA-N

SMILES string

CC1=C(C(C(NNC(C(C2=CC(F)=CC(F)=C2)O)=O)=O)=CC=C1O)CC

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Related Categories

Biochem/physiol Actions

EMD638683 is an orally active and highly selective serum/glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 = 3 μM against HeLa cellular NDRG1 phosphorylation) that significantly decreased blood pressure in fructose-treated mice but not in control saline-treated or in SGK1-knockout animals (4460 ppm in chow, ~600 mg/kg/day). EMD638683 promotes radiation-induced suicidal death of CaCo-2 colon tumor cells in vitro (50 μM) and decreases the number of colonic tumors following chemical carcinogenesis in vivo (4460 ppm in chow).
Orally active and highly selective serum/glucocorticoid-regulated kinase 1 (SGK1) inhibitor with anti-cancer and anti-hypertensive efficacy in vitro and in vivo.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000392726
0000392726
0000229064
0000229072
0000236164

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EMD638683, a novel SGK inhibitor with antihypertensive potency
Cellular Physiology and Biochemistry, 28(1), 137-146 (2011)
SGK1.1 limits brain damage after status epilepticus through M current-dependent and independent mechanisms
Neurobiology of Disease, 153, 105317-105317 (2021)
Complement C3a activates osteoclasts by regulating the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma
Cancer Biology & Medicine, 18(3), 721-733 (2021)
An increase in alveolar fluid clearance induced by hyperinsulinemia in obese rats with LPS-induced acute lung injury
Respiratory Physiology & Neurobiology, 279279, 103470-103470 (2020)
Joshua A Mason et al.
Cell reports, 34(11), 108821-108821 (2021-03-18)
Loss of integrin-mediated attachment to extracellular matrix (ECM) proteins can trigger a variety of cellular changes that affect cell viability. Foremost among these is the activation of anoikis, caspase-mediated cell death induced by ECM detachment. In addition, loss of ECM
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