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Merck

T0632

Sodium thioglycolate

≥96.5% (iodometric)

Synonym(s):

Mercaptoacetic acid sodium salt, Thioglycolic acid sodium salt

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About This Item

Linear Formula:
HSCH2COONa
CAS Number:
367-51-1
Molecular Weight:
114.10
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
24899901
EC Number:
206-696-4
Beilstein/REAXYS Number:
4569109
MDL number:
MFCD00043386

Product Name

Sodium thioglycolate, ≥96.5% (iodometric)

InChI key

GNBVPFITFYNRCN-UHFFFAOYSA-M

InChI

1S/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1

SMILES string

[Na+].[O-]C(=O)CS

assay

≥96.5% (iodometric)

form

powder

color

white to off-white

useful pH range

6.7 (20 °C, 100 g/L)

mp

>300 °C (lit.)

solubility

water: ~609.1 g/L at 20 °C (OECD Test Guideline 105)

storage temp.

−20°C

Quality Level

200

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Application

Sodium thioglycolate has been used:
  • as a growth supplement in enrichment media and to study its effect on Arcobacter
  • in influenza hemagglutinin formulation in order to reduce disulfide-mediated cross-linking and early potency loss
  • in electron microscopy

Biochem/physiol Actions

Sodium thioglycolate acts as reducing agent and is suitable for anaerobic and microaerophilic bacterial growth.
Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.

Disclaimer

At room temperature, concentrations over 70% in water tend to form 1-2% thioglycolides per month which hydrolyze to the original free compound when made acidic or alkaline. The 70% solution oxidizes in air but is stable at room temperature when tightly closed. Thioglycolate salts may also lose purity on storage. The exclusion of air does not materially improve stability.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Aquatic Chronic 3 - Met. Corr. 1 - Skin Sens. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB4587
SDBB4586
SDBB4585
SDBB4584
SDBB4583

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Tatsuya Omotezako et al.
Scientific reports, 7, 44226-44226 (2017-03-11)
The maternal contribution to the oocyte cytoplasm plays an important role during embryogenesis because it is involved in early cell fate specification and embryonic axis establishment. However, screening projects targeting maternal factors have only been conducted in a limited number
Laura Navone et al.
Waste management (New York, N.Y.), 102, 149-160 (2019-11-05)
Textile waste presents a serious environmental problem with only a small fraction of products from the fashion industry collected and re-used or recycled. The problem is exacerbated in the case of post-consumer waste by the mixture of different natural and
Kim De Paepe et al.
PeerJ, 7, e6293-e6293 (2019-02-01)
Undigestible, insoluble food particles, such as wheat bran, are important dietary constituents that serve as a fermentation substrate for the human gut microbiota. The first step in wheat bran fermentation involves the poorly studied solubilization of fibers from the complex
Clinical Ophthalmology: Contemporary Perspectives - E-Book, 176-176 (2012)
Improved stability of recombinant hemagglutinin using a formulation containing sodium thioglycolate
Rhodes DG, et al.
Vaccine, 33(44), 6011-6016 (2015)
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Product Information Sheet - T0632

Product Information Sheet

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