T1019
(±)-Thiopental
Synonym(s):
5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid, Pentothal
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About This Item
Empirical Formula (Hill Notation):
C11H18N2O2S
CAS Number:
Molecular Weight:
242.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
200-984-3
MDL number:
InChI key
IUJDSEJGGMCXSG-UHFFFAOYSA-N
InChI
1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
SMILES string
CCCC(C)C1(CC)C(=O)NC(=S)NC1=O
drug control
USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada
solubility
ethanol: complete 50 mg/mL
originator
Abbott
Quality Level
Gene Information
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Biochem/physiol Actions
Thiopental is an anesthetic that decreases cerebral metabolic rate without altering the blood flow or oxygen consumption.
Application
(±)-Thiopental was used to transiently anesthetize rats for in vivo NMR spectroscopy.
Features and Benefits
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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B M Jucker et al.
The Journal of biological chemistry, 272(16), 10464-10473 (1997-04-18)
The effects of increased plasma free fatty acids (FFA) on insulin-dependent whole body glucose disposal, skeletal muscle glycolysis, glycogen synthesis, pyruvate versus FFA/ketone oxidation, and glucose 6-phosphate (Glu-6-P) were investigated in the awake rat. A control group (glycerol-infused) and high
Cerebral circulation and metabolism during thiopental anesthesia and hyper-ventilation in man.
E C PIERCE et al.
The Journal of clinical investigation, 41, 1664-1671 (1962-08-01)
Colleen K Loo et al.
Journal of affective disorders, 142(1-3), 233-240 (2012-08-04)
Preliminary evidence suggests that the use of ketamine during electroconvulsive therapy (ECT) may be neuroprotective against cognitive impairment and have synergistic antidepressant effects. This study tested whether the addition of ketamine reduced cognitive impairment and enhanced efficacy over a course
Fong Huynh et al.
Therapeutic drug monitoring, 31(2), 153-169 (2009-01-30)
Thiopental is a barbiturate used in traumatic brain injuries (TBIs) to reduce intracranial pressure (ICP) and to manage cerebral ischemia. As thiopental follows Michaelis-Menten kinetics, therapeutic drug monitoring (TDM) has been used in practice to improve efficacy and reduce adverse
Ibrahim M Alharfi et al.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 14(2), 203-209 (2013-01-15)
To determine the occurrence rate of central diabetes insipidus in pediatric patients with severe traumatic brain injury and to describe the clinical, injury, biochemical, imaging, and intervention variables associated with mortality. Retrospective chart and imaging review. Children's Hospital, level 1
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