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V5765

Vascular Endothelial Growth Factor 165 human

≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

Synonym(s):

Vascular Endothelial Growth Factor 165

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
dimer 42 kDa (glycosylated)
Impurities:
<0.075 EU/μg
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Product Name

VEGF165, recombinant, expressed in HEK 293 cells, suitable for cell culture

biological source

human

Quality Level

200

recombinant

expressed in HEK 293 cells

description

Vascular Endothelial Growth Factor 165 human

assay

≥95% (SDS-PAGE)

form

lyophilized powder

potency

<10 ng/mL ED50

quality

endotoxin tested

mol wt

dimer 42 kDa (glycosylated)

packaging

pkg of 10 μg, pkg of 50 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.075 EU/μg

color

white

solubility

water: soluble

UniProt accession no.

P15692

storage temp.

−20°C

Gene Information

human ... VEGFA(7422)

General description

VEGF165 is expressed in human HEK 293 cells as a glycosylated homodimer with an apparent molecular mass of 45 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Biochem/physiol Actions

VEGF165 belongs to the PDGF/VEGF growth factor family characterized by the presence of eight conserved cysteine residues and a cystine knot structure. VEGF is secreted by the majority of tumor cells and initiates angiogenesis by activating endothelial cells of existing blood vessels and promoting their migration.
VEGF has also been implicated in correlation with poor prognosis in breast cancer.
In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries).

Analysis Note

The specific activity was determined by the dose-dependent stimulation of the proliferation of HUVEC cells (human umbilical vein endothelial cells).

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000413724
0000413725
0000413725
0000413724
0000233619

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Articles

VEGF Pathway

Read review on VEGF signaling pathway (Vascular endothelial growth factor (VEGF)/VEGF receptor) and find related products.

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