W4262

1400W dihydrochloride

Name: 1400W dihydrochloride
Brand: SIGMA

>98%, potent and selective iNOS inhibitor , solid

Synonym(s):

N-([3-(Aminomethyl)phenyl]methyl)ethanimidamide dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₅N₃· 2 HCl

CAS Number:

214358-33-5

Molecular Weight:

250.17

UNSPSC Code:

12352200

PubChem Substance ID:

24278778

NACRES:

NA.77

MDL number:

MFCD03428622

Product Name

1400W dihydrochloride, >98%, solid

SMILES string

Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1

InChI key

WDJHSQZCZGPGAA-UHFFFAOYSA-N

InChI

1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H

assay

>98%

form

solid

storage condition

desiccated

originator

GlaxoSmithKline

shipped in

wet ice

storage temp.

−20°C

Application

1400W dihydrochloride has been used:

as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
to study its efficacy on renal ischemia/ reperfusion injury in rats
as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation

Biochem/physiol Actions

1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS).

Features and Benefits

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity.

Simone Bido et al.

Nature communications, 12(1), 6237-6237 (2021-10-31)

Recent findings in human samples and animal models support the involvement of inflammation in the development of Parkinson's disease. Nevertheless, it is currently unknown whether microglial activation constitutes a primary event in neurodegeneration. We generated a new mouse model by

Downregulation of Nitric Oxide Collaborated with Radiotherapy to Promote Anti-Tumor Immune Response via Inducing CD8+ T Cell Infiltration.

Jieyu Xu et al.

International journal of biological sciences, 16(9), 1563-1574 (2020-04-01)

The production of nitric oxide (NO) is a key feature of immunosuppressive myeloid cells, which impair T cell activation and proliferation via reversibly blocking interleukin-2 receptor signaling. NO is mainly produced from L-arginine by inducible NO synthase (iNOS). Moreover, L-arginine

Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion

Kesik V, et al.

The Journal of Surgical Research, 157(1), e97-e105 (2009)

Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor.

L L Thomsen et al.

Cancer research, 57(15), 3300-3304 (1997-08-01)

We have investigated the effect of N-(3-(aminomethyl)benzyl)acetamidine (1400W), a novel and highly selective inhibitor for inducible NOS (iNOS), on in vivo growth of solid tumors expressing iNOS. For the EMT6 murine mammary adenocarcinoma, in which iNOS is expressed in the

Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS

Ersoz N, et al.

Renal Failure, 31(8), 704-710 (2009)

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1400W dihydrochloride

>98%, potent and selective iNOS inhibitor , solid

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About This Item

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Product Name

SMILES string

InChI key

InChI

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form

storage condition

originator

shipped in

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Description

Application

Biochem/physiol Actions

Features and Benefits

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Storage Class

wgk

flash_point_f

flash_point_c

ppe

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