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Merck

X1126

Xylazine

≥99%, Alpha-2 adrenergic agonist

Synonym(s):

2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine

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About This Item

Empirical Formula (Hill Notation):
C12H16N2S
CAS Number:
7361-61-7
Molecular Weight:
220.33
NACRES:
NA.77
PubChem Substance ID:
24902128
UNSPSC Code:
12352200
EC Number:
230-902-1
MDL number:
MFCD00057908

Product Name

Xylazine, ≥99%

InChI key

BPICBUSOMSTKRF-UHFFFAOYSA-N

InChI

1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)

SMILES string

Cc1cccc(C)c1NC2=NCCCS2

assay

≥99%

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

storage temp.

−20°C

Quality Level

200

Application

Xylazine has been used to anaesthetise experimental animals.

Biochem/physiol Actions

α2-adrenoceptor agonist, sedative, muscle relaxant.
Xylazine when used along with ketamine is considered to be a potent and safe anaesthetic in experimental animal. It is known to elevate the hepatic release of glucose, which aggravates to hyperglycemia.

General description

Xylazine is soluble in methanol (50 mg/ml), yielding a clear, colorless solution. It is also soluble in dilute HCl acid and in chloroform. Xylazine is practically insoluble in water and in alkali solutions.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL6717
BCCJ4616
BCCG2096
BCCC5196
BCCB0368

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MIND model for triple-negative breast cancer in syngeneic mice for quick and sequential progression analysis of lung metastasis
Ghosh A, et al.
PLoS ONE, 13(5), e0198143-e0198143 (2018)
Acute reversible cataract induced by xylazine and by ketamine-xylazine anesthesia in rats and mice
Calderone L, et al.
Experimental Eye Research, 42(4), 331-337 (1986)
Effect of xylazine on plasma glucose, glucagon and insulin concentrations in sheep
Brockman, RP
Research in Veterinary Science, 30(3), 383-384 (1981)
Naomi Van Gassen et al.
European journal of immunology, 45(5), 1482-1493 (2015-02-04)
Pancreas injury by partial duct ligation (PDL) activates a healing response, encompassing β-cell neogenesis and proliferation. Macrophages (MΦs) were recently shown to promote β-cell proliferation after PDL, but they remain poorly characterized. We assessed myeloid cell diversity and the factors
Hannah T Nickles et al.
American journal of physiology. Lung cellular and molecular physiology, 307(1), L27-L37 (2014-05-13)
The pathogenesis of ventilator-induced lung injury has predominantly been attributed to overdistension or mechanical opening and collapse of alveoli, whereas mechanical strain on the airways is rarely taken into consideration. Here, we hypothesized that mechanical ventilation may cause significant airway
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Product Information Sheet - X1126

Product Information Sheet

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