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658408 AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem

A cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 that displays apoptotic and antiproliferative properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC D722757, α-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide, 5H4

Primary Target: apoptotic and antiproliferative properties
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      581797-29-7C₁₈H₁₃F₃N₂O₃
      Description
      OverviewA cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 (Cat. No. 658401) that displays apoptotic and antiproliferative properties (IC50 = 1.7 µM, 2.8 µM and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively). Shown to inhibit IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly reduce lymph node cellularity in a murine B and T cell lymphoma model (1 mg per animal, i.p.) in vivo.
      Catalogue Number658408
      Brand Family Calbiochem®
      SynonymsNSC D722757, α-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide, 5H4
      References
      ReferencesGu, L., et al. 2005. Bioorg. Med. Chem. 13, 4269.
      Product Information
      CAS number581797-29-7
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₈H₁₃F₃N₂O₃
      Chemical formulaC₁₈H₁₃F₃N₂O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetapoptotic and antiproliferative properties
      Primary Target IC<sub>50</sub>1.7 µM, 2.8 µM and 6.1 µM for displaying apoptotic and antiproliferative properties in 2E8, Baf/3 and Jurkat cells, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      658408 0

      Documentation

      AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      658408

      References

      Reference overview
      Gu, L., et al. 2005. Bioorg. Med. Chem. 13, 4269.

      Citations

      Title
    • Yona Goldshmit, et al. (2004) SOCS2 Induces Neurite Outgrowth by Regulation of Epidermal Growth Factor Receptor Activation. Journal of Biological Chemistry 279, 16349-16355.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsNSC D722757, α-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide, 5H4
      DescriptionA cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 (Cat. No. 658401) that displays apoptotic and antiproliferative properties (IC50 = 1.7 µM, 2.8 µM and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively). Shown to inhibit IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly reduce lymph node cellularity in a murine B and T cell lymphoma model (1 mg per animal, i.p.) in vivo.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number581797-29-7
      Chemical formulaC₁₈H₁₃F₃N₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (0.5 mg/ml) or Methanol
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
      Toxicity Standard Handling
      ReferencesGu, L., et al. 2005. Bioorg. Med. Chem. 13, 4269.
      Citation
    • Yona Goldshmit, et al. (2004) SOCS2 Induces Neurite Outgrowth by Regulation of Epidermal Growth Factor Receptor Activation. Journal of Biological Chemistry 279, 16349-16355.
      		•