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407294 αA-Interferon, Human, Recombinant, E. coli

407294
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Products

Numero di catalogoConfezionamento Qtà/conf
407294-5MU Fiala di plastica 5 mu
Description
OverviewRecombinant, human αA-interferon expressed in E. coli. Antiviral, anti-neoplastic agent. αA-Interferon exhibits therapeutic potential with chronic viral hepatitis, polycythemia vera, and various malignancies. It enhances natural killer cell activity, suppresses bone marrow function, and induces apoptotic cell death in non-melanoma skin cancer. NOTE: 1MU = 1,000,000 units.
Note: 1 MU = 1,000,000 units.
Catalogue Number407294
Brand Family Calbiochem®
SynonymsrhIFN-αA
References
ReferencesFujishima, H., et al. 1998. Int. J. Cancer 76, 423.
Haria, M., and Benfield, P. 1995. Drugs 50, 873.
Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
Product Information
Activity≥5 x 10⁶ units/ml
Unit of DefinitionOne unit of interferon per ml of medium will cause a 50% inhibition of VSV-induced cytopathic effect on bovine MDBK cells. Units are determined with respect to the NIH international reference standard for human αA-IFN. Dilute in aqueous buffer containing at least 0.1% BSA or HSA.
FormLiquid
FormulationIn PBS containing 0.1% BSA.
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by SDS-PAGE
Specific Activity≥2.8 x 10⁸ units/mg protein
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

αA-Interferon, Human, Recombinant, E. coli MSDS

Titolo

Scheda di sicurezza (MSDS) 

αA-Interferon, Human, Recombinant, E. coli Certificati d'Analisi

TitoloNumero di lotto
407294

Riferimenti bibliografici

Panoramica delle referenze
Fujishima, H., et al. 1998. Int. J. Cancer 76, 423.
Haria, M., and Benfield, P. 1995. Drugs 50, 873.
Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.

Citazioni

Titolo
  • Sambit K. Nanda and Michael D. Baron. (2006) Rinderpest virus blocks type I and type II interferon action: role of structural and nonstructural proteins. Journal of Virology 80, 7555-7568.
  • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
  • Scheda tecnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision13-May-2008 RFH
    SynonymsrhIFN-αA
    DescriptionRecombinant, human αA-interferon expressed in E. coli. Antiviral, anti-neoplastic agent. αA-Interferon exhibits therapeutic potential in chronic viral hepatitis, polycythemia vera, and various malignancies. It enhances natural killer cell activity, suppresses bone marrow function, and induces apoptotic cell death in non-melanoma skin cancer.
    FormLiquid
    FormulationIn PBS containing 0.1% BSA.
    Purity≥95% by SDS-PAGE
    Specific activity≥2.8 x 10⁸ units/mg protein
    Activity≥5 x 10⁶ units/ml
    Unit definitionOne unit of interferon per ml of medium will cause a 50% inhibition of VSV-induced cytopathic effect on bovine MDBK cells. Units are determined with respect to the NIH international reference standard for human αA-IFN. Dilute in aqueous buffer containing at least 0.1% BSA or HSA.
    SolubilityDilute only in buffers containing protein such as 0.1% BSA.
    Storage ≤ -70°C
    Avoid freeze/thaw
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
    Toxicity Standard Handling
    Merck USA index14, 4990
    ReferencesFujishima, H., et al. 1998. Int. J. Cancer 76, 423.
    Haria, M., and Benfield, P. 1995. Drugs 50, 873.
    Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
    Citation
  • Sambit K. Nanda and Michael D. Baron. (2006) Rinderpest virus blocks type I and type II interferon action: role of structural and nonstructural proteins. Journal of Virology 80, 7555-7568.
  • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.